Influence of host genetics on the severity of coccidioidomycosis.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Louie, L. ; Ng, S. ; Hajjeh, R. ; Johnson, R. ; Vugia, D. ; Werner, S. B. ; Talbot, R. ; Klitz, W.
• Description:
  Coccidioidomycosis, a mild flulike illness in approximately 40% of infected persons, progresses to severe pulmonary or disseminated disease in 1% to 10% of symptomatic cases. We examined host genetic influences on disease severity among class II HLA loci and the ABO blood group. Participants included African-American, Caucasian, and Hispanic persons with mild or severe disseminated coccidioidomycosis from Kern County, California. Among Hispanics, predisposition to symptomatic disease and severe disseminated disease is associated with blood types A and B, respectively. The HLA class II DRB1*1301 allele marks a pre-disposition to severe disseminated disease in each of the three groups. Reduced risk for severe disease is associated with DRB1*0301-DQB1*0201 among Caucasians and Hispanics and with DRB1*1501-DQB1*0602 among African-Americans. These data support the hypothesis that host genes, in particular HLA class II and the ABO blood group, influence susceptibility to severe coccidioidomycosis.
• Subjects:
  Abo Blood-Group System Alleles Black People Case-Control Studies Coccidioidomycosis Genetic Predisposition To Disease Hispanic Or Latino Histocompatibility Antigens Class Ii Humans Phenotype Severity Of Illness Index White People

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• Source:
  Emerg Infect Dis. 5(5):672-680.
• Document Type:
  Journal Article
• Place as Subject:
  California
• Volume:
  5
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f1125db2f07d3e251aac8c53a22e593022df6049cb392cc19e67684c33ce3a40
• Download URL:
  https://stacks.cdc.gov/view/cdc/14902/cdc_14902_DS1.pdf
• File Type:
  [PDF - 81.94 KB ]