Burden of Respiratory Viruses in Children Less Than 2 Years Old in a Community-based Longitudinal US Birth Cohort

Details

• Alternative Title:
  Clin Infect Dis
• Personal Author:
  Teoh, Zheyi ; Conrey, Shannon ; McNeal, Monica ; Burrell, Allison ; Burke, Rachel M. ; Mattison, Claire ; McMorrow, Meredith ; Payne, Daniel C. ; Morrow, Ardythe L. ; Staat, Mary Allen
• Description:
  Background. ; Respiratory viral infections are a major cause of morbidity and hospitalization in young children. Nevertheless, the population burden of respiratory viral infections, especially asymptomatic cases, is not known due to the lack of prospective community-based cohort studies with intensive monitoring. ; Methods. ; To address this gap, we enacted the PREVAIL cohort, a Centers for Disease Control and Prevention–sponsored birth cohort in Cincinnati, Ohio, where children were followed from 0 to 2 years of age. Weekly text surveys were administered to record acute respiratory illnesses (ARIs), which were defined as the presence of cough or fever (≥38°C). Weekly midturbinate nasal swabs were collected and tested using the Luminex Respiratory Pathogen Panel, which detected 16 viral pathogens. Viral infection was defined as ≥1 positive tests from the same virus or viral subtype ≤30 days of a previous positive test. Maternal report and medical chart abstractions identified healthcare utilization. ; Results. ; From 4/2017 to 7/2020, 245 mother–infant pairs were recruited and followed. From the 13 781 nasal swabs tested, a total of 2211 viral infections were detected, of which 821 (37%) were symptomatic. Children experienced 9.4 respiratory viral infections/child-year; half were rhinovirus/enterovirus. Viral ARI incidence was 3.3 episodes/child-year. Emergency department visits or hospitalization occurred with only 15% of respiratory syncytial virus infections, 10% of influenza infections, and only 4% of all viral infections. Regardless of pathogen, most infections were asymptomatic or mild. ; Conclusions. ; Respiratory viral infections are common in children 0–2 years. Most viral infections are asymptomatic or non–medically attended, underscoring the importance of community-based cohort studies.
• Subjects:
  • Infant
  • Humans
  • Child, Preschool
  • Respiratory Tract Infections
  • Birth Cohort
  • Viruses
  • Virus Diseases
  • Respiratory Syncytial Virus Infections
• Keywords:
  • birth cohort
  • influenza virus
  • respiratory viruses
  • RSV
  • viral infections
• Source:
  Clin Infect Dis. 77(6):901-909
• Pubmed ID:
  37157868
• Pubmed Central ID:
  PMC10838707
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; T32 ES010957/ES/NIEHS NIH HHSUnited States/ ; UL1 TR001425/TR/NCATS NIH HHSUnited States/
• Volume:
  77
• Issue:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/147679/cdc_147679_DS1.pdf
• File Type:
  [PDF - 693.80 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8b23b7604e9249b0d4172127c4143a289a22613eef56c169b96cb905bfda38ed