Rapid Detection of Ceftazidime/Avibactam Susceptibility/Resistance in Enterobacterales by Rapid CAZ/AVI NP Test

Nordmann, Patrice; Bouvier, Maxime; Delaval, Adam; Tinguely, Camille; Poirel, Laurent; Sadek, Mustafa

doi:10.3201/eid3002.221398

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Rapid Detection of Ceftazidime/Avibactam Susceptibility/Resistance in Enterobacterales by Rapid CAZ/AVI NP Test

2 2024
By Nordmann, Patrice ; Bouvier, Maxime ; Delaval, Adam ; ...
http://dx.doi.org/10.3201/eid3002.221398
Source: Emerg Infect Dis. 2024; 30(2):255-261

[PDF-872.07 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Nordmann, Patrice ; Bouvier, Maxime ; Delaval, Adam ; Tinguely, Camille ; Poirel, Laurent ; ... More +

Nordmann, Patrice ; Bouvier, Maxime ; Delaval, Adam ; Tinguely, Camille ; Poirel, Laurent ; Sadek, Mustafa Less -
Description:

We developed a novel culture-based test, the Rapid CAZ/AVI NP test, for rapid identification of ceftazidime/avibactam susceptibility/resistance in Enterobacterales. This test is based on glucose metabolization upon bacterial growth in the presence of a defined concentration of ceftazidime/avibactam (128/53 μg/mL). Bacterial growth is visually detectable by a red to yellow color change of red phenol, a pH indicator. A total of 101 well characterized enterobacterial isolates were used to evaluate the test performance. This test showed positive percent agreement of 100% and negative percent agreement of 98.5% with overall percent agreement of 99%, by comparison with the MIC gradient strip test (Etest) taken as the reference standard method. The Rapid CAZ/AVI NP test had only 1.5% major errors and 0% extremely major errors. This test is rapid (result within 2 hours 45 minutes), reliable, affordable, easily interpretable, and easy to implement in clinical microbiology laboratories without requiring any specific equipment.
Subjects:

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Azabicyclo Compounds Ceftazidime Enterobacteriaceae Gammaproteobacteria Laboratories
Keywords:

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Antimicrobial Resistance Bacteria Ceftazidime/Avibactam Enterobacterales Nordmann Poirel Test NP Test Rapid CAZ/AVI NP Test Rapid Detection Rapid Diagnostics Susceptibility/Resistance
Source:

Emerg Infect Dis. 2024; 30(2):255-261
Pubmed ID:

38270160
Pubmed Central ID:

PMC10826745
Document Type:

Journal Article
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

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urn:sha256:af35b549fb526aaeae40dce37f06fcd0db44a4680fd9e53a2f2c5f25bb261c3e
Download URL:

https://stacks.cdc.gov/view/cdc/147338/cdc_147338_DS1.pdf
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	22-1398-F.gif	gif
	22-1398-F.jpg	jpeg
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