Carbapenem-Resistant and Extended-Spectrum β-Lactamase–Producing Enterobacterales in Children, United States, 2016–2020

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Grome, Heather N. ; Grass, Julian E. ; Duffy, Nadezhda ; Bulens, Sandra N. ; Ansari, Uzma ; Campbell, Davina ; Lutgring, Joseph D. ; Gargis, Amy S. ; Masters, Thao ; Kent, Alyssa G. ; McKay, Susannah L. ; Smith, Gillian ; Wilson, Lucy E. ; Vaeth, Elisabeth ; Evenson, Bailey ; Dumyati, Ghinwa ; Tsay, Rebecca ; Phipps, Erin ; Flores, Kristina ; Wilson, Christopher D. ; Czaja, Christopher A. ; Johnston, Helen ; Janelle, Sarah J. ; Lynfield, Ruth ; O’Malley, Sean ; Vagnone, Paula Snippes ; Maloney, Meghan ; Nadle, Joelle ; Guh, Alice Y.
• Description:
  2019–2020 at 6 US sites. Among 159 CRE cases in children (median age 5 years), CRE was isolated from urine for 131 (82.4%) and blood from 20 (12.6%). Annual CRE incidence rate (cases/100,000 population) was 0.47–0.87. Among 207 ESBL-E cases in children (median age 6 years), ESBL-E was isolated from urine of 196 (94.7%) and blood of 8 (3.9%). Annual ESBL-E incidence rate was 26.5 in 2019 and 19.63 in 2020. CRE and ESBL-E rates were >2-fold higher among infants than other age groups. Most CRE and ESBL-E cases were healthcare-associated community-onset (68 [43.0%] for CRE vs. 40 [23.7%] for ESBL-E) or community-associated (43 [27.2%] for CRE vs. 109 [64.5%] for ESBL-E). Programs to detect, prevent, and treat multidrug-resistant infections must include pediatric populations (particularly the youngest) and outpatient settings.
• Subjects:
  Adolescent Anti-Bacterial Agents Beta-Lactamases Carbapenem-Resistant Enterobacteriaceae Carbapenems Child Child, Preschool Enterobacteriaceae Enterobacteriaceae Infections History, 21st Century Humans Infant Male Microbial Sensitivity Tests

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• Keywords:
  Antimicrobial Resistance Bacteria Carbapenem-resistant Enterobacterales Child Communicable Diseases Enterobacterales Epidemiology Extended-spectrum β-lactamase-producing Enterobacterales Public Health United States
• Source:
  Emerg Infect Dis. 2024; 30(6):1104-1114
• Pubmed ID:
  38781979
• Pubmed Central ID:
  PMC11138972
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  30
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4d603f61c01780edf1ec28565118a593c74c3513a38e5a8185951f964fbd2d7b
• Download URL:
  https://stacks.cdc.gov/view/cdc/156992/cdc_156992_DS1.pdf
• File Type:
  [PDF - 866.31 KB ]