HIV-1 Genetic Diversity in Antenatal Cohort, Canada

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Akouamba, Bertine S. ; Viel, Janique ; Charest, Hugues ; Merindol, Natacha ; Samson, Johanne ; Lapointe, Normand ; Brenner, Bluma G. ; Lalonde, Richard ; Harrigan, P. Richard ; Boucher, Marc ; Soudeyns, Hugo
• Description:
  We studied HIV genetic diversity in a cohort of 127 pregnant, HIV-infected women who received prenatal care at Sainte-Justine Hospital in Montreal, Canada, between 1999 and 2003. Clade assignments were derived by phylogenetic analysis of amplified pol sequences. Genotyping was successful in 103 of 127 women, 59 (57.3%) of whom were infected with clade B HIV-1, and 44 (42.7%) with nonclade B viruses, including subtypes A, C, D, F, G, and H. Four sequences remained unassigned. Forty-three of 44 women infected with non-clade B viruses were newcomers from sub-Saharan Africa, and subtype identity was consistent with those circulating in their countries of origin. These results highlight the epidemiologic importance of non-B HIV-1 in antenatal populations in a large North American urban center, underscore the influence of population movements on clade intermixing, and identify a group of patients who could be targeted for surveillance and drug therapy followup.
• Subjects:
  Adult Cluster Analysis Cohort Studies Female Gene Products, Pol Genetic Variation HIV-1 HIV Infections Humans Keywords: AIDS Phylogeny Pol Gene Products, Human Immunodeficiency Virus Pregnancy Pregnancy Complications, Infectious Research Reverse Transcriptase Polymerase Chain Reaction RNA, Viral Urban Population Viral Load Viral Subtypes

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• Source:
  Emerg Infect Dis. 11(8):1230-1234.
• Document Type:
  Journal Article
• Place as Subject:
  Africa South of the Sahara ; Asia ; Canada ; Caribbean Region
• Location:
  Africa ; Asia ; North America ; Caribbean
• Volume:
  11
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:39e8f6aa63e157b3324454c401abebdec0e0c0d816cf348b584f17e486a75a3f
• Download URL:
  https://stacks.cdc.gov/view/cdc/14722/cdc_14722_DS1.pdf
• File Type:
  [PDF - 104.18 KB ]