Childhood Hemolytic Uremic Syndrome, United Kingdom and Ireland

Lynn, Richard M.; O'Brien, Sarah J.; Taylor, C. Mark; Adak, Goutam K.; Chart, Henrik; Cheasty, Tom; Coia, John E.; Gillespie, Iain A.; Locking, Mary E.; Reilly, William J.; Smith, Henry R.; Waters, Aoife; Willshaw, Geraldine A.

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Childhood Hemolytic Uremic Syndrome, United Kingdom and Ireland

Supporting Files Public Domain

Apr 2005
By Lynn, Richard M. ; O'Brien, Sarah J. ; Taylor, C. Mark ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Lynn, Richard M. ; O'Brien, Sarah J. ; Taylor, C. Mark ; Adak, Goutam K. ; Chart, Henrik ; Cheasty, Tom ; Coia, John E. ; Gillespie, Iain A. ; Locking, Mary E. ; Reilly, William J. ; Smith, Henry R. ; Waters, Aoife ; Willshaw, Geraldine A.
Description:

We conducted prospective surveillance of childhood hemolytic uremic syndrome (HUS) from 1997 to 2001 to describe disease incidence and clinical, epidemiologic and microbiologic characteristics. We compared our findings, where possible, with those of a previous study conducted from 1985 to 1988. The average annual incidence of HUS for the United Kingdom and Ireland (0.71/100,000) was unchanged from 1985 to 1988. The overall early mortality had halved, but the reduction in mortality was almost entirely accounted for by improved outcome in patients with diarrhea-associated HUS. The principal infective cause of diarrhea-associated HUS was Shiga toxin-producing Escherichia coli O157 (STEC O157), although in the 1997-2001 survey STEC O157 phage type (PT) 21/28 had replaced STEC O157 PT2 as the predominant PT. The risk of developing diarrhea-associated HUS was significantly higher in children infected with STEC O157 PT 2 and PT 21/28 compared with other PTs. Hypertension as a complication of HUS was greatly reduced in patients with diarrhea-associated HUS.
Subjects:

Adolescent Child Child, Preschool Escherichia Coli Infections Escherichia Coli O157 Feces Female Hemolytic-Uremic Syndrome Humans Male Population Surveillance Prospective Studies Time Factors
Source:

Emerg Infect Dis. 11(4):590-596.
Document Type:

Journal Article
Place as Subject:

United Kingdom
Volume:

11
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:ba34058678479e092598cf8893acc9070d659835766066eb41924c41b6bb7bb9
Download URL:

https://stacks.cdc.gov/view/cdc/14717/cdc_14717_DS1.pdf
File Type:

[PDF - 198.11 KB ]

File Language:

English

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