Nosocomial Infection with Vancomycin-dependent Enterococci1
Published Date:Jul 2004
Source:Emerg Infect Dis. 10(7):1277-1281.
Gram-Positive Bacterial Infections
Microbial Sensitivity Tests
Nutritionally Deficient Microorganisms
Vancomycin-dependent Enterococci (VDE)
Vancomycin-resistant Enterococci (VRE)
Description:We report three patients infected with unique strains of vancomycin-dependent enterococci. Two were first infected by genetically identical strains of vancomycin-resistant enterococci (VRE). All three patients had much greater exposure to vancomycin and third-generation cephalosporins than did two control groups (patients infected with VRE and hospitalized patients without enterococcal infections). While antimicrobial pressure promotes nosocomial colonization by VRE, prolonged exposure to vancomycin may foster the transition from vancomycin resistance to dependence.
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