Respiratory Picornaviruses and Respiratory Syncytial Virus as Causative Agents of Acute Expiratory Wheezing in Children

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Jartti, Tuomas ; Lehtinen, Pasi ; Vuorinen, Tytti ; Österback, Riikka ; van den Hoogen, Bernadette ; Osterhaus, Albert D.M.E. ; Ruuskanen, Olli
• Description:
  We studied the viral etiology of acute expiratory wheezing (bronchiolitis, acute asthma) in 293 hospitalized children in a 2-year prospective study in Finland. A potential causative viral agent was detected in 88% of the cases. Eleven different viruses were represented. Respiratory syncytial virus (RSV) (27%), enteroviruses (25%), rhinovirus (24%), and nontypable rhino/enterovirus (16%) were found most frequently. In infants, RSV was found in 54% and respiratory picornaviruses (rhinovirus and enteroviruses) in 42% of the cases. In older children, respiratory picornaviruses dominated (65% of children ages 1-2 years and 82% of children ages > or =3 years). Human metapneumovirus was detected in 4% of all children and in 11% of infants. To prevent and treat acute expiratory wheezing illnesses in children, efforts should be focused on RSV, enterovirus, and rhinovirus infections.
• Subjects:
  Adolescent Age Factors Antigens, Viral Asthma Bronchiolitis Child Child, Preschool Finland Humans Infant Picornaviridae Picornaviridae Infections Prospective Studies Research Respiratory Sounds Respiratory Syncytial Viruses Respiratory Syncytial Virus Infections Reverse Transcriptase Polymerase Chain Reaction RNA, Viral Seasons

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• Source:
  Emerg Infect Dis. 10(6):1095-1101.
• Document Type:
  Journal Article
• Place as Subject:
  Finland
• Location:
  Europe
• Volume:
  10
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:dcdd6c19039b0bd791849bedb3cab0fdfc84cf1d96726eb0abbc3c7c9c168103
• Download URL:
  https://stacks.cdc.gov/view/cdc/14459/cdc_14459_DS1.pdf
• File Type:
  [PDF - 299.08 KB ]