Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Lu, Karen ; Asano, Rumi ; Davies, Julian
Lu, Karen ; Asano, Rumi ; Davies, Julian Less -
Description:
Avoparcin, a glycopeptide antimicrobial agent related to vancomycin, has been used extensively as a growth promoter in animal feeds for more than 2 decades, and evidence has shown that such use contributed to the development of vancomycin-resistant enterococci. A cluster that includes three genes, vanH, vanA, and vanX, is required for high-level resistance to glycopeptides. In the vancomycin producer Amycolatopsis orientalis C329.2, homologs of these genes are present, suggesting an origin for the cluster. We found substantial bacterial DNA contamination in animal feed-grade avoparcin. Furthermore, nucleotide sequences related to the cluster vanHAX are present in this DNA, suggesting that the prolonged use of avoparcin in agriculture led to the uptake of glycopeptide resistance genes by animal commensal bacteria, which were subsequently transferred to humans.
Subjects:
[+]
Agriculture Animal Feed Animals Anti-Bacterial Agents Antimicrobial Agents DNA, Bacterial Enterococci Glycopeptides Humans Multigene Family Prophylactic Research Resistance Therapeutic Vancomycin Resistance
Source:
Emerg Infect Dis. 10(4):679-683.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:4b68aa7bc9c071aab07f165c43ee290e22ed1c1564bb281d069504261eee3ca9
Download URL:
https://stacks.cdc.gov/view/cdc/14416/cdc_14416_DS1.pdf
File Type:

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