Interferon-β 1a and SARS Coronavirus Replication

Hensley, Lisa E.; Fritz, Elizabeth A.; Jahrling, Peter B.; Karp, Christopher; Huggins, John W.; Geisbert, Thomas W.

i

Interferon-β 1a and SARS Coronavirus Replication

Supporting Files Public Domain

Feb 2004
By Hensley, Lisa E. ; Fritz, Elizabeth A. ; Jahrling, Peter B. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Hensley, Lisa E. ; Fritz, Elizabeth A. ; Jahrling, Peter B. ; Karp, Christopher ; Huggins, John W. ; Geisbert, Thomas W.
Description:

A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made it a critical public health issue. Because no effective treatments are available, an intensive effort is under way to identify and test promising antiviral drugs. Here, we report that recombinant human interferon-beta 1a potently inhibits SARS coronavirus replication in vitro.
Subjects:

Animals Antiviral Agents Cercopithecus Aethiops Cytopathogenic Effect, Viral Humans Interferon-Beta Interferon Type I Recombinant Proteins Sars Virus Severe Acute Respiratory Syndrome Vero Cells Virus Replication
Source:

Emerg Infect Dis. 10(2):317-319.
Document Type:

Journal Article
Volume:

10
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:d529fdb8fc33b85ed23dc4dc8e7fa29f4fed0ebe82fcab337cc9764d1e8c5e2a
Download URL:

https://stacks.cdc.gov/view/cdc/14403/cdc_14403_DS1.pdf
File Type:

[PDF - 1.64 MB ]

File Language:

English

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