Community-Acquired Methicillin-Resistant Staphylococcus aureus Carrying Panton-Valentine Leukocidin Genes: Worldwide Emergence

Vandenesch, François; Naimi, Timothy; Enright, Mark C.; Lina, Gerard; Nimmo, Graeme R.; Heffernan, Helen; Liassine, Nadia; Bes, Michèle; Greenland, Timothy; Reverdy, Marie-Elisabeth; Etienne, Jerome

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Community-Acquired Methicillin-Resistant Staphylococcus aureus Carrying Panton-Valentine Leukocidin Genes: Worldwide Emergence

Supporting Files Public Domain

Aug 2003
By Vandenesch, François ; Naimi, Timothy ; Enright, Mark C. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Vandenesch, François ; Naimi, Timothy ; Enright, Mark C. ; Lina, Gerard ; Nimmo, Graeme R. ; Heffernan, Helen ; Liassine, Nadia ; Bes, Michèle ; Greenland, Timothy ; Reverdy, Marie-Elisabeth ; Etienne, Jerome
Description:

Infections caused by community-acquired (CA)-methicillin--resistant Staphylococcus aureus (MRSA) have been reported worldwide. We assessed whether any common genetic markers existed among 117 CA-MRSA isolates from the United States, France, Switzerland, Australia, New Zealand, and Western Samoa by performing polymerase chain reaction for 24 virulence factors and the methicillin-resistance determinant. The genetic background of the strain was analyzed by pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). The CA-MRSA strains shared a type IV SCCmec cassette and the Panton-Valentine leukocidin locus, whereas the distribution of the other toxin genes was quite specific to the strains from each continent. PFGE and MLST analysis indicated distinct genetic backgrounds associated with each geographic origin, although predominantly restricted to the agr3 background. Within each continent, the genetic background of CA-MRSA strains did not correspond to that of the hospital-acquired MRSA.
Subjects:

Bacterial Toxins Communicable Diseases Communicable Diseases, Emerging Community-acquired Infections Electrophoresis, Gel, Pulsed-Field Emerging Bacterial Infections Enterotoxins Exotoxins Humans Leukocidins Methicillin Resistance Microbial Sensitivity Tests Research Staphylococcus Aureus
Source:

Emerg Infect Dis. 9(8):978-984
Pubmed ID:

12967497
Pubmed Central ID:

PMC3020611
Document Type:

Journal Article
Volume:

9
Issue:

8
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:db6f016dd39f52c9570b0d2473ad8bbab57a8df730553d6614805786bb2204df
Download URL:

https://stacks.cdc.gov/view/cdc/14255/cdc_14255_DS1.pdf
File Type:

[PDF - 353.48 KB ]

File Language:

English

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