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Fluoroquinolone and Macrolide Treatment Failure in Pneumococcal Pneumonia and Selection of Multidrug-Resistant Isolates
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  1. Fluoroquinolone Resistance in Penicillin-resistant Streptococcus pneumoniae Clones, Spain
    Personal Author:
    de la Campa, Adela G.; Balsalobre, Luz; Ardanuy, Carmen; Fenoll, Asunción; Pérez-Trallero, Emilio; Liñares, Josefina;
    Corporate Authors:
    Spanish Pneumococcal Infection Study Network G03/103
    Published Date:
    Oct 2004
    Source:
    Emerg Infect Dis. 10(10):1751-1759.
    Description:
    Among 2,882 Streptococcus pneumoniae sent to the Spanish Reference Laboratory during 2002, 75 (2.6%) were ciprofloxacin-resistant. Resistance was associated with older patients (3.9% in adults and 7.2% in patients > or =65 years of age), with isolati...
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  2. Dead Bugs Don’t Mutate: Susceptibility Issues in the Emergence of Bacterial Resistance
    Personal Author:
    Stratton, Charles W.
    Published Date:
    Jan 2003
    Source:
    Emerg Infect Dis. 9(1):10-16.
    Description:
    The global emergence of antibacterial resistance among common and atypical respiratory pathogens in the last decade necessitates the strategic application of antibacterial agents. The use of bactericidal rather than bacteriostatic agents as first-lin...
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  3. Macrolide Resistance in Adults with Bacteremic Pneumococcal Pneumonia
    Personal Author:
    Metlay, Joshua P.; Fishman, Neil O.; Joffe, Marshall M.; Kallan, Michael J.; Chittams, Jesse L.; Edelstein, Paul H.;
    Published Date:
    Aug 2006
    Source:
    Emerg Infect Dis. 12(8):1223-1230.
    Description:
    We conducted a case-control study of adults with bacteremic pneumococcal pneumonia to identify factors associated with macrolide resistance. Study participants were identified through population-based surveillance in a 5-county region surrounding Phi...
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  4. Relative Fitness of Fluoroquinolone-resistant Streptococcus pneumoniae
    Personal Author:
    Johnson, Crystal N.; Briles, David E.; Benjamin, William H.; Hollingshead, Susan K.; Waites, Ken B.;
    Published Date:
    Jun 2005
    Source:
    Emerg Infect Dis. 11(6):814-820.
    Description:
    Fluoroquinolone resistance in Streptococcus pneumoniae is primarily mediated by point mutations in the quinolone resistance-determining regions of gyrA and parC. Antimicrobial resistance mutations in housekeeping genes often decrease fitness of micro...
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  5. Fluoroquinolone and Other Antimicrobial Resistance in Invasive Pneumococci, Hong Kong, 1995–2001
    Personal Author:
    Ho, Pak-Leung; Que, Tak-Lun; Chiu, Susan S.; Yung, Raymond W. H.; Ng, Tak-Keung; Tsang, Dominic N.C.; Seto, Wing-Hong; Lau, Yu-Lung;
    Published Date:
    Jul 2004
    Source:
    Emerg Infect Dis. 10(7):1250-1257.
    Description:
    We determined the susceptibilities of 265 invasive isolates of pneumococci obtained during 1995 to 2001 in Hong Kong to 11 antimicrobial agents and their serotypes. Overall, 62.6% isolates were susceptible to penicillin, 20% were intermediately resis...
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