Fluoroquinolone and Macrolide Treatment Failure in Pneumococcal Pneumonia and Selection of Multidrug-Resistant Isolates

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Pérez-Trallero, Emilio ; Marimon, José M. ; Iglesias, Luis ; Larruskain, Julián
• Description:
  Streptococcus pneumoniae serotype 3, isolated from a penicillin-allergic patient and initially susceptible to fluoroquinolones, macrolides, lincosamides, quinupristin-dalfopristin, and telithromycin, became resistant to all these drugs during treatment. Mutations in the parC and gyrA and in the 23S rRNA and the ribosomal protein L22 genes were detected in the resistant isolates.
• Subjects:
  Aged Anti-Bacterial Agents Anti-Infective Agents Ciprofloxacin Clarithromycin Dispatch Drug Resistance Drug Resistance, Multiple, Bacterial Fluoroquinolones Humans In Vivo Selection Levofloxacin Macrolides Male Microbial Sensitivity Tests Pneumococcal Infections Point Mutation Quinupristin-Dalfopristin Serotype 3 Streptococcus Pneumoniae Telithromycin Treatment Failure

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• Source:
  Emerg Infect Dis. 9(9):1159-1162.
• Document Type:
  Journal Article
• Volume:
  9
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4e18786bc488eabe283661ee4866d4c61cd6b90bd09a667948e9ccff289688d1
• Download URL:
  https://stacks.cdc.gov/view/cdc/14199/cdc_14199_DS1.pdf
• File Type:
  [PDF - 307.47 KB ]