Rifampin- and Multidrug-Resistant Tuberculosis in Russian Civilians and Prison Inmates: Dominance of the Beijing Strain Family

Drobniewski, Francis; Balabanova, Yanina; Ruddy, Michael; Weldon, Laura; Jeltkova, Katya; Brown, Timothy; Malomanova, Nadezdna; Elizarova, Elvira; Melentyey, Alexander; Mutovkin, Ebgeny; Zhakharova, Svetlana; Fedorin, Ivan

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Rifampin- and Multidrug-Resistant Tuberculosis in Russian Civilians and Prison Inmates: Dominance of the Beijing Strain Family

Supporting Files Public Domain

Nov 2002
By Drobniewski, Francis ; Balabanova, Yanina ; Ruddy, Michael ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Drobniewski, Francis ; Balabanova, Yanina ; Ruddy, Michael ; Weldon, Laura ; Jeltkova, Katya ; Brown, Timothy ; Malomanova, Nadezdna ; Elizarova, Elvira ; Melentyey, Alexander ; Mutovkin, Ebgeny ; Zhakharova, Svetlana ; Fedorin, Ivan
Description:

Consecutive patient cultures (140) of Mycobacteriium tuberculosis were collected from five Russian civilian and prison tuberculosis laboratories and analyzed for rifampin (rpoB) and isoniazid resistance (inhA, katG, ahpC); transmission of Beijing family isolates; and the importance of prison and previous therapy in drug resistance. Rifampin, isoniazid, and multidrug resistance occurred in 58.2%, 51.6%, and 44.7% of cultures, respectively; 80% of prison cultures were rifampin resistant. Spoligotyping and variable number tandem repeat (VNTR) fingerprinting divided the isolates into 43 groups. Spoligotyping demonstrated that a high proportion (68.1%) of patients were infected with Beijing family strains and that most (69.1%) were rifampin resistant; the highest proportion (81.6%) occurred in prison. One VNTR subgroup (42435) comprised 68 (72.3%) of the Beijing isolates with a small number of IS6110 types; 50 (73.5%) were rifampin resistant. Rifampin-resistant Beijing isolates are dominant within the patient population, especially among prisoners, and threaten treatment programs.
Subjects:

Antitubercular Agents Drug Resistance, Multiple, Bacterial Female Humans Male Minisatellite Repeats Mutation Mycobacterium Tuberculosis Prisoners Research Rifampin Tuberculosis
Source:

Emerg Infect Dis. 8(11):1320-1326.
Document Type:

Journal Article
Place as Subject:

China ; Russia
Location:

Asia ; Europe
Volume:

8
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:d8ee4439d6737209fc8176335dc723b795cade12e7c04259781b208133bcf1fd
Download URL:

https://stacks.cdc.gov/view/cdc/14100/cdc_14100_DS1.pdf
File Type:

[PDF - 691.16 KB ]

File Language:

English

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