Identifying the Sources of Tuberculosis in Young Children: A Multistate Investigation

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Sun, Sumi J. ; Bennett, Diane E. ; Flood, Jennifer ; Loeffler, Ann M. ; Kammerer, Steve ; Ellis, Barbara A.
• Description:
  To better understand the molecular epidemiology of tuberculosis (TB) transmission for culture-confirmed patients <5 years of age, data were analyzed from a population-based study conducted in seven U.S. sites from 1996 to 2000. Mycobacterium tuberculosis isolates were genotyped with IS6110-based restriction fragment length polymorphism analysis and spoligotyping. Case-patient data were obtained from the Centers for Disease Control and Prevention s national tuberculosis registry and health department records. Routine public health investigations conducted by local health departments identified suspected source patients for 57 (51%) of 111 culture-confirmed patients <5 years of age. For 8 (15%) of 52 culture-confirmed patients <5 years of age and their suspected source patients with complete genotyping results, genotypes suggested infection with different TB strains. Potential differences between sources for patients <5 years of age and source patients that transmitted TB to adolescent and adult patients were identified.
• Subjects:
  Adolescent Adult Antitubercular Agents Child Child, Preschool Contact Tracing Databases, Factual Dispatch DNA, Bacterial DNA Fingerprinting Drug Resistance, Multiple, Bacterial Female Humans Infant Male Molecular Epidemiology Polymorphism, Restriction Fragment Length Risk Factors Sentinel Surveillance Tuberculosis

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• Source:
  Emerg Infect Dis. 8(11):1216-1223.
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Location:
  North America
• Volume:
  8
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:c33b29d251a4024d6bed4723c5dd4ed06e02f53dd78e981076e019d44ba8b34a
• Download URL:
  https://stacks.cdc.gov/view/cdc/14076/cdc_14076_DS1.pdf
• File Type:
  [PDF - 256.37 KB ]