Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Ellis, Barbara A. ; Crawford, Jack T. ; Braden, Christopher R. ; McNabb, Scott J. N. ; Moore, Marisa ; ... More +
Ellis, Barbara A. ; Crawford, Jack T. ; Braden, Christopher R. ; McNabb, Scott J. N. ; Moore, Marisa ; Kammerer, Steve Less -
Corporate Authors:
National Tuberculosis Genotyping and Surveillance Network Work Group
Description:
We conducted a population-based study to assess demographic and risk-factor correlates for the most frequently occurring Mycobacterium tuberculosis genotypes from tuberculosis (TB) patients. The study included all incident, culture-positive TB patients from seven sentinel surveillance sites in the United States from 1996 to 2000. M. tuberculosis isolates were genotyped by IS6110-based restriction fragment length polymorphism and spoligotyping. Genotyping was available for 90% of 11923 TB patients. Overall, 48% of cases had isolates that matched those from another patient, including 64% of U.S.-born and 35% of foreign-born patients. By logistic regression analysis, risk factors for clustering of genotypes were being male, U.S.-born, black, homeless, and infected with HIV; having pulmonary disease with cavitations on chest radiograph and a sputum smear with acid-fast bacilli; and excessive drug or alcohol use. Molecular characterization of TB isolates permitted risk correlates for clusters and specific genotypes to be described and provided information regarding cluster dynamics over time.
Subjects:
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Adolescent Adult Aged Antitubercular Agents Child Child, Preschool Cluster Analysis DNA, Bacterial Drug Resistance, Multiple, Bacterial Female Genotype Humans Infant Longitudinal Studies Male Middle Aged Molecular Epidemiology Polymorphism, Restriction Fragment Length Racial Groups Risk Factors Sentinel Surveillance Time Factors Tuberculosis
Source:
Emerg Infect Dis. 8(11):1197-1209.
Document Type:
Journal Article
Place as Subject:
United States
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:59dfb22b0ae76022e3449117959c1dd8ab0a4a7d7937ff42edfbb0d895650321
Download URL:
https://stacks.cdc.gov/view/cdc/3121/cdc_3121_DS1.pdf
File Type:

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