Molecular Epidemiology of Tuberculosis in a Sentinel Surveillance Population

Ellis, Barbara A.; Crawford, Jack T.; Braden, Christopher R.; McNabb, Scott J. N.; Moore, Marisa; Kammerer, Steve

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Molecular Epidemiology of Tuberculosis in a Sentinel Surveillance Population

Published Date:

Nov 2002

Source:

Emerg Infect Dis. 8(11):1197-1209.

[PDF - 365.41 KB]

Details:

Personal Authors:

Ellis, Barbara A. ; Crawford, Jack T. ; Braden, Christopher R. ; McNabb, Scott J. N. ; Moore, Marisa ; ... More ▼

Corporate Authors:

National Tuberculosis Genotyping and Surveillance Network Work Group

Keywords:

[+]

Description:

We conducted a population-based study to assess demographic and risk-factor correlates for the most frequently occurring Mycobacterium tuberculosis genotypes from tuberculosis (TB) patients. The study included all incident, culture-positive TB patients from seven sentinel surveillance sites in the United States from 1996 to 2000. M. tuberculosis isolates were genotyped by IS6110-based restriction fragment length polymorphism and spoligotyping. Genotyping was available for 90% of 11923 TB patients. Overall, 48% of cases had isolates that matched those from another patient, including 64% of U.S.-born and 35% of foreign-born patients. By logistic regression analysis, risk factors for clustering of genotypes were being male, U.S.-born, black, homeless, and infected with HIV; having pulmonary disease with cavitations on chest radiograph and a sputum smear with acid-fast bacilli; and excessive drug or alcohol use. Molecular characterization of TB isolates permitted risk correlates for clusters and specific genotypes to be described and provided information regarding cluster dynamics over time.

Document Type:

Journal Article

Collection(s):

CDC Public Access
Emerging Infectious Diseases

Supporting Files:

02-0403-F1.gif	image/gif
02-0403-F1.jpg	image/jpeg
02-0403-F2.gif	image/gif
02-0403-F2.jpg	image/jpeg
02-0403-F3.gif	image/gif
02-0403-F3.jpg	image/jpeg
02-0403-Fa.gif	image/gif
02-0403-Fa.jpg	image/jpeg
02-0403_FinalD.nxml	text/plain
license.txt	text/plain

No Related Documents.

You May Also Like:

Protocol for a population-based molecular epidemiology study of tuberculosis transmission in a high HIV-burden setting: the Botswana Kopanyo study

Personal Author:

Zetola, N M; Modongo, C; Moonan, P K; Click, E; Oeltmann, J E; Shepherd, J; Finlay, A;

Published:

May 09 2016

Source:

BMJ Open. 2016; 6(5).

Description:

Introduction : Mycobacterium tuberculosis (Mtb) is transmitted from person to person via airborne droplet nuclei. At the community level, Mtb transmission depends on the exposure venue, infectiousness of the tuberculosis (TB) index case and the susce...

File Type:

[PDF - 1.37 MB]
Determinants of Cluster Size in Large, Population-Based Molecular Epidemiology Study of Tuberculosis, Northern Malawi

Personal Author:

Glynn, Judith R.; Crampin, Amelia C.; Traore, Hamidou; Chaguluka, Steve; Mwafulirwa, Donex T.; Alghamdi, Saad; Ngwira, Bagrey M.M.; Yates, Malcolm D.; Drobniewski, Francis D.; Fine, Paul E.M.;

Published:

Jul 2008

Source:

Emerg Infect Dis. 14(7):1060-1066.

Description:

Tuberculosis patients with identical strains of Mycobacterium tuberculosis are described as clustered. Cluster size may depend on patient or strain characteristics. In a 7-year population-based study of tuberculosis in Karonga District, Malawi, clust...

File Type:

[PDF - 300.69 KB]
Sampling Bias in the Molecular Epidemiology of Tuberculosis

Personal Author:

Murray, Megan

Published:

Apr 2002

Source:

Emerg Infect Dis. 8(4):363-369.

Description:

Among the goals of the molecular epidemiology of infectious disease are to quantify the extent of ongoing transmission of infectious agents and to identify host- and strain-specific risk factors for disease spread. I demonstrate the potential bias in...

File Type:

[PDF - 2.10 MB]
Statewide Molecular Epidemiology of Mycobacterium tuberculosis Transmission in a Moderate- to Low-Incidence State: Are Contact Investigations Enough?

Personal Author:

Cronin, Wendy A.; Golub, Jonathan E.; Lathan, Monica J.; Mukasa, Leonard N.; Hooper, Nancy; Razeq, Jafar H.; Baruch, Nancy G.; Mulcahy, Donna; Benjamin, William H.; Magder, Laurence S.; Strickland, G. Thomas; Bishai, William R.;

Published:

Nov 2002

Source:

Emerg Infect Dis. 8(11):1271-1279.

Description:

To assess the circumstances of recent transmission of tuberculosis (TB) (progression to active disease <2 years after infection), we obtained DNA fingerprints for 1172 (99%) of 1179 Mycobacterium tuberculosis isolates collected from Maryland TB patie...

File Type:

[PDF - 306.51 KB]
Outcomes of Sentinel Lymph Node Dissection Alone vs. Axillary Lymph Node Dissection in Early Stage Invasive Lobular Carcinoma: A Retrospective Study of the Surveillance, Epidemiology and End Results (SEER) Database

Personal Author:

Wang, Jun; Mittendorf, Elizabeth A.; Sahin, Aysegul A.; Yi, Min; Caudle, Abigail; Hunt, Kelly K.; Wu, Yun;

Published:

Feb 25 2014

Source:

PLoS One. 2014; 9(2).

Description:

Background : The American College of Surgeons Oncology Group (ACOSOG) Z0011 trial demonstrated no difference in local-regional recurrence (LRR), disease-specific survival (DSS) or overall survival (OS) for sentinel lymph node dissection (SLND) and co...

File Type:

[PDF - 569.42 KB]