Molecular Epidemiology of Tuberculosis in a Sentinel Surveillance Population

Ellis, Barbara A.; Crawford, Jack T.; Braden, Christopher R.; McNabb, Scott J. N.; Moore, Marisa; Kammerer, Steve

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Molecular Epidemiology of Tuberculosis in a Sentinel Surveillance Population

Supporting Files Public Domain

Nov 2002
By Ellis, Barbara A. ; Crawford, Jack T. ; Braden, Christopher R.

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Ellis, Barbara A. ; Crawford, Jack T. ; Braden, Christopher R. ; McNabb, Scott J. N. ; Moore, Marisa ; Kammerer, Steve
Corporate Authors:

National Tuberculosis Genotyping and Surveillance Network Work Group
Description:

We conducted a population-based study to assess demographic and risk-factor correlates for the most frequently occurring Mycobacterium tuberculosis genotypes from tuberculosis (TB) patients. The study included all incident, culture-positive TB patients from seven sentinel surveillance sites in the United States from 1996 to 2000. M. tuberculosis isolates were genotyped by IS6110-based restriction fragment length polymorphism and spoligotyping. Genotyping was available for 90% of 11923 TB patients. Overall, 48% of cases had isolates that matched those from another patient, including 64% of U.S.-born and 35% of foreign-born patients. By logistic regression analysis, risk factors for clustering of genotypes were being male, U.S.-born, black, homeless, and infected with HIV; having pulmonary disease with cavitations on chest radiograph and a sputum smear with acid-fast bacilli; and excessive drug or alcohol use. Molecular characterization of TB isolates permitted risk correlates for clusters and specific genotypes to be described and provided information regarding cluster dynamics over time.
Subjects:
Source:

Emerg Infect Dis. 8(11):1197-1209.
Document Type:

Journal Article
Place as Subject:

United States
Location:

North America
Volume:

8
Issue:

11
Download URL:

https://stacks.cdc.gov/view/cdc/3121/cdc_3121_DS1.pdf
File Type:

[PDF - 365.41 KB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha-512:2566076adeb6a6c8706c31e2d701a046a48cfe7c07cac80fc0cb739aa2a6a7182aa86c08f63cdbdc3fa347111038e7334e040788a3fba0ddbe1cb574efa6e880

File Language:

English

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