Molecular Epidemiology of Tuberculosis in a Sentinel Surveillance Population
Published Date:Nov 2002
Source:Emerg Infect Dis. 8(11):1197-1209.
Corporate Authors:National Tuberculosis Genotyping and Surveillance Network Work Group
Continental Population Groups
Drug Resistance, Multiple, Bacterial
Insertion Sequence Elements
Polymorphism, Restriction Fragment Length
Restriction Fragment-length Polymorphism
Description:We conducted a population-based study to assess demographic and risk-factor correlates for the most frequently occurring Mycobacterium tuberculosis genotypes from tuberculosis (TB) patients. The study included all incident, culture-positive TB patients from seven sentinel surveillance sites in the United States from 1996 to 2000. M. tuberculosis isolates were genotyped by IS6110-based restriction fragment length polymorphism and spoligotyping. Genotyping was available for 90% of 11923 TB patients. Overall, 48% of cases had isolates that matched those from another patient, including 64% of U.S.-born and 35% of foreign-born patients. By logistic regression analysis, risk factors for clustering of genotypes were being male, U.S.-born, black, homeless, and infected with HIV; having pulmonary disease with cavitations on chest radiograph and a sputum smear with acid-fast bacilli; and excessive drug or alcohol use. Molecular characterization of TB isolates permitted risk correlates for clusters and specific genotypes to be described and provided information regarding cluster dynamics over time.
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