Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Ellis, Barbara A. ; Crawford, Jack T. ; Braden, Christopher R. ; McNabb, Scott J. N. ; Moore, Marisa ; ... More +
Ellis, Barbara A. ; Crawford, Jack T. ; Braden, Christopher R. ; McNabb, Scott J. N. ; Moore, Marisa ; Kammerer, Steve ; Less -
Corporate Authors:
National Tuberculosis Genotyping and Surveillance Network Work Group ;
Description:
We conducted a population-based study to assess demographic and risk-factor correlates for the most frequently occurring Mycobacterium tuberculosis genotypes from tuberculosis (TB) patients. The study included all incident, culture-positive TB patients from seven sentinel surveillance sites in the United States from 1996 to 2000. M. tuberculosis isolates were genotyped by IS6110-based restriction fragment length polymorphism and spoligotyping. Genotyping was available for 90% of 11923 TB patients. Overall, 48% of cases had isolates that matched those from another patient, including 64% of U.S.-born and 35% of foreign-born patients. By logistic regression analysis, risk factors for clustering of genotypes were being male, U.S.-born, black, homeless, and infected with HIV; having pulmonary disease with cavitations on chest radiograph and a sputum smear with acid-fast bacilli; and excessive drug or alcohol use. Molecular characterization of TB isolates permitted risk correlates for clusters and specific genotypes to be described and provided information regarding cluster dynamics over time.
Subject:
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Adolescent
Adult
Aged
Antitubercular Agents
Child
Child, Preschool
Cluster Analysis
DNA, Bacterial
Drug Resistance, Multiple, Bacterial
Female
Genotype
Humans
Infant
Longitudinal Studies
Male
Middle Aged
Molecular Epidemiology
Polymorphism, Restriction Fragment Length
Racial Groups
Risk Factors
Sentinel Surveillance
Time Factors
Tuberculosis

Source:
Emerg Infect Dis. 8(11):1197-1209. ;
Document Type:
Journal Article ;
Place as Subject:
United States ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:59dfb22b0ae76022e3449117959c1dd8ab0a4a7d7937ff42edfbb0d895650321
File Type:

Supporting Files

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