Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes

Cardosa, Mary Jane; Perera, David; Brown, Betty A.; Cheon, Doosung; Chan, Hung Ming; Chan, Kwai Peng; Cho, Haewol; McMinn, Peter

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Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes

Supporting Files Public Domain

Apr 2003
By Cardosa, Mary Jane ; Perera, David ; Brown, Betty A. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Cardosa, Mary Jane ; Perera, David ; Brown, Betty A. ; Cheon, Doosung ; Chan, Hung Ming ; Chan, Kwai Peng ; Cho, Haewol ; McMinn, Peter
Description:

This study provides a comprehensive overview of the molecular epidemiology of human enterovirus 71 (HEV71) in the Asia-Pacific region from 1997 through 2002. Phylogenetic analysis of the VP4 and VP1 genes of recent HEV71 strains indicates that several genogroups of the virus have been circulating in the Asia-Pacific region since 1997. The first of these recent outbreaks, described in Sarawak (Malaysian Borneo) in 1997, was caused by genogroup B3. This outbreak was followed by large outbreaks in Taiwan in 1998, caused by genogroup C2, and in Perth (Western Australia) in 1999, where viruses belonging to genogroups B3 and C2 cocirculated. Singapore, Taiwan, and Sarawak had HEV71 epidemics in 2000, caused predominantly by viruses belonging to genogroup B4; however, large numbers of fatalities were observed only in Taiwan. HEV71 was identified during an epidemic of hand, foot and mouth disease in Korea; that epidemic was found to be due to viruses constituting a new genogroup, C3.
Subjects:

Disease Outbreaks Enterovirus Enterovirus Infections Foot And Mouth Disease Genotype Hand Human Enterovirus 71 Humans Molecular Epidemiology Molecular Epidemiology Of Human Enterovirus 71 Strains And Recent Outbreaks In The Asia-Pacific Region: Comparative Analysis Of The VP1 And VP4 Genes Neurologic Disease Phylogeny Research
Source:

Emerg Infect Dis. 9(4):462-468
Pubmed ID:

12702227
Pubmed Central ID:

PMC2957976
Document Type:

Journal Article
Place as Subject:

Asia, Southeastern
Location:

Asia
Volume:

9
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:42f0a6761a404caa7683ea57a119c258bdd3446c65eed8f9ba5687381857fb0d
Download URL:

https://stacks.cdc.gov/view/cdc/14068/cdc_14068_DS1.pdf
File Type:

[PDF - 239.05 KB ]

File Language:

English

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