Effectiveness of Vaccines and Antiviral Drugs in Preventing Severe and Fatal COVID-19, Hong Kong

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Cheung, Yue Yat Harrison ; Lau, Eric Ho Yin ; Yin, Guosheng ; Lin, Yun ; Cowling, Benjamin J. ; Lam, Kwok Fai
• Description:
  We compared the effectiveness and interactions of molnupiravir and nirmatrelvir/ritonavir and 2 vaccines, CoronaVac and Comirnaty, in a large population of inpatients with COVID-19 in Hong Kong. Both the oral antiviral drugs and vaccines were associated with lower risks for all-cause mortality and progression to serious/critical/fatal conditions (study outcomes). No significant interaction effects were observed between the antiviral drugs and vaccinations; their joint effects were additive. If antiviral drugs were prescribed within 5 days of confirmed COVID-19 diagnosis, usage was associated with lower risks for the target outcomes for patients >60, but not <60, years of age; no significant clinical benefit was found if prescribed beyond 5 days. Among patients >80 years of age, 3-4 doses of Comirnaty vaccine were associated with significantly lower risks for target outcomes. Policies should encourage COVID-19 vaccination, and oral antivirals should be made accessible to infected persons within 5 days of confirmed diagnosis.
• Subjects:
  • Antiviral Agents
  • BNT162 Vaccine
  • Child, Preschool
  • COVID-19
  • COVID-19 / prevention & control
  • COVID-19 Testing
  • COVID-19 Vaccines
  • Humans
  • Vaccines
• Keywords:
  • molnupiravir
  • nirmatrelvir
  • ritonavir
  • CoronaVac
  • Comirnaty
  • COVID-19
  • respiratory infections
  • severe acute respiratory syndrome coronavirus 2
  • SARS-CoV-2
  • SARS
  More +
• Source:
  Emerg Infect Dis. 2024; 30(1):70-78
• Pubmed ID:
  38040664
• Pubmed Central ID:
  PMC10756371
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Hong Kong
• Volume:
  30
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/140567/cdc_140567_DS1.pdf
• File Type:
  [PDF - 2.12 MB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:a458c78485a302937606674542c1be28b30448e7c3c40e0f84447884b685554b3f6836a4996480c51396c68cbd0ccf48dcaae3357078ee5c60999a76ebc4c53f