Population-Based Evaluation of Vaccine Effectiveness against SARS-CoV-2 Infection, Severe Illness, and Death, Taiwan

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lee, Cheng-Yi ; Kuo, Hung-Wei ; Liu, Yu-Lun ; Chuang, Jen-Hsiang ; Chou, Jih-Haw
• Description:
  Taiwan provided several COVID-19 vaccine platforms: mRNA (BNT162b2, mRNA-1273), adenoviral vector-based (AZD1222), and protein subunit (MVC-COV1901). After Taiwan shifted from its zero-COVID strategy in April 2022, population-based evaluation of vaccine effectiveness (VE) became possible. We conducted an observational cohort study of 21,416,151 persons to examine VE against SARS-CoV-2 infection, moderate and severe illness, and death during March 22, 2021-September 30, 2022. After adjusting for age and sex, we found that persons who completed 3 vaccine doses (2 primary, 1 booster) or received MVC-COV1901 as the primary series had the lowest hospitalization incidence (0.04-0.20 cases/100,000 person-days). We also found 95.8% VE against hospitalization for 3 doses of BNT162b2, 91.0% for MVC-COV1901, 81.8% for mRNA-1273, and 65.7% for AZD1222, which had the lowest overall VE. Our findings indicated that protein subunit vaccines provide similar protection against SARS-CoV-2---associated hospitalization as mRNA vaccines and can inform mix-and-match vaccine selection in other countries.
• Subjects:
  2019-nCoV Vaccine MRNA-1273 BNT162 Vaccine ChAdOx1 NCoV-19 Cohort Studies COVID-19 Vaccines COVID-19/epidemiology COVID-19/prevention & Control Humans SARS-CoV-2 / Genetics Vaccine Efficacy
• Keywords:
  AZD1222 BNT162b2 Coronavirus Coronavirus Disease COVID-19 Mix-and-match MRNA-1273 MVC-COV1901 Population-based Cohort Study Respiratory Infections SARS SARS-CoV-2 Severe Acute Respiratory Syndrome Coronavirus 2 Taiwan Vaccine Effectiveness Viruses Zoonoses

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• Source:
  Emerg Infect Dis. 2024; 30(3):478-489
• Pubmed ID:
  38295401
• Pubmed Central ID:
  PMC10902541
• Document Type:
  Journal Article
• Place as Subject:
  Taiwan
• Volume:
  30
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:63c1f79153856cb39f00cfbb6da091bc0e03648c51c2d01fe56fc677df756274
• Download URL:
  https://stacks.cdc.gov/view/cdc/148780/cdc_148780_DS1.pdf
• File Type:
  [PDF - 5.13 MB ]