Maintaining Fluoroquinolone Class Efficacy: Review of Influencing Factors

Scheld, W. Michael

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Maintaining Fluoroquinolone Class Efficacy: Review of Influencing Factors

Published Date:

Jan 2003

Source:

Emerg Infect Dis. 9(1):1-9.

[PDF-224.38 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Scheld, W. Michael

Description:

Previous experience with antimicrobial resistance has emphasized the importance of appropriate stewardship of these pharmacotherapeutic agents. The introduction of fluoroquinolones provided potent new drugs directed primarily against gram-negative pathogens, while the newer members of this class demonstrate more activity against gram-positive species, including Streptococcus pneumoniae. Although these agents are clinically effective against a broad range of infectious agents, emergence of resistance and associated clinical failures have prompted reexamination of their use. Appropriate use revolves around two key objectives: 1) only prescribing antimicrobial therapy when it is beneficial and 2) using the agents with optimal activity against the expected pathogens. Pharmacodynamic principles and properties can be applied to achieve the latter objective when prescribing agents belonging to the fluoroquinolone class. A focused approach emphasizing "correct-spectrum" coverage may reduce development of antimicrobial resistance and maintain class efficacy.

Subject:

[+]

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

	02-0277.nxml	text/plain
	license.txt	text/plain

No Related Documents.

You May Also Like:

Quinolone Safety and Efficacy

Personal Author:

Bellomo, Spartaco

Published Date:

Jun 2005

Source:

Emerg Infect Dis. 11(6):985-987.

File Type:

[PDF - 121.93 KB]
Factors Influencing Fluoroquinolone Resistance

Personal Author:

Sahm, Daniel F.; Thornsberry, Clyde; Jones, Mark E.; Karlowsky, James A.;

Published Date:

Dec 2003

Source:

Emerg Infect Dis. 9(12):1651-1654.

File Type:

[PDF - 162.56 KB]
Quinolone Safety and Efficacy More Important than Potency

Personal Author:

Frothingham, Richard

Published Date:

Jan 2004

Source:

Emerg Infect Dis. 10(1):156-157.

File Type:

[PDF - 24.58 KB]
Vancomycin-resistant Enterococcus faecalis in Serbia

Personal Author:

Stošović, Branka; Stepanović, Srdjan; Donabedian, Susan; Tošić, Tanja; Jovanović, Milica;

Published Date:

Jan 2004

Source:

Emerg Infect Dis. 10(1):157-158.

File Type:

[PDF - 26.46 KB]
Update of Practice Guidelines for the Management of Community-Acquired Pneumonia in Immunocompetent Adults

Personal Author:

Mandell, Lionel A.; Bartlett, John G.; Dowell, Scott F.; File, Thomas M.; Musher, Daniel M.; Whitney, Cynthia;

Published Date:

November 03 2003

Source:

Clin Infect Dis. 2003; 37(11):1405-1433

File Type:

[PDF - 231.96 KB]