Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Scheld, W. Michael
Description:
Previous experience with antimicrobial resistance has emphasized the importance of appropriate stewardship of these pharmacotherapeutic agents. The introduction of fluoroquinolones provided potent new drugs directed primarily against gram-negative pathogens, while the newer members of this class demonstrate more activity against gram-positive species, including Streptococcus pneumoniae. Although these agents are clinically effective against a broad range of infectious agents, emergence of resistance and associated clinical failures have prompted reexamination of their use. Appropriate use revolves around two key objectives: 1) only prescribing antimicrobial therapy when it is beneficial and 2) using the agents with optimal activity against the expected pathogens. Pharmacodynamic principles and properties can be applied to achieve the latter objective when prescribing agents belonging to the fluoroquinolone class. A focused approach emphasizing "correct-spectrum" coverage may reduce development of antimicrobial resistance and maintain class efficacy.
Subject:
[+]
Aged
Aged, 80 And Over
Anti-Infective Agents
Antibiotic Resistance
Bacterial Infections
Ciprofloxacin
Drug Resistance, Bacterial
Fluoroquinolones
Gatifloxacin
Gram-Negative Bacteria
Gram-Positive Bacteria
Humans
Levofloxacin
Middle Aged
Moxifloxacin
Ofloxacin
Perspective
Pseudomonas Aeruginosa
Respiratory Tract Infections
Risk Factors
Streptococcus Pneumoniae
Urinary Tract Infections
Fluoroquinolones
Perspective

Source:
Emerg Infect Dis. 9(1):1-9.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:21122314cfba3f7dc688510cb25d7d3cb432fe2196c2296005e9a3e852819898
File Type:

Supporting Files

• 	02-0277.nxml	txt
  	license.txt	txt

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