Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model

Temime, L.; Boëlle, P.Y.; Courvalin, P.; Guillemot, D.

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Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model

Supporting Files Public Domain

Apr 2003
By Temime, L. ; Boëlle, P.Y. ; Courvalin, P. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Temime, L. ; Boëlle, P.Y. ; Courvalin, P. ; Guillemot, D.
Description:

Streptococcus pneumoniae and Neisseria meningitidis have very similar mechanisms of resistance to penicillin G. Although penicillin resistance is now common in S. pneumoniae, it is still rare in N. meningitidis. Using a mathematical model, we studied determinants of this difference and attempted to anticipate trends in meningococcal resistance to penicillin G. The model predicted that pneumococcal resistance in a population similar to that of France might emerge after 20 years of widespread use of beta-lactam antibiotics; this period may vary from 10 to 30 years. The distribution of resistance levels became bimodal with time, a pattern that has been observed worldwide. The model suggests that simple differences in the natural history of colonization, interhuman contact, and exposure to beta-lactam antibiotics explain major differences in the epidemiology of resistance of S. pneumoniae and N. meningitidis.
Subjects:

Antibiotic Resistance, Mathematical Models, Streptococcus Pneumonia, Neisseria Meningitidis Bacterial Proteins Carrier Proteins Hexosyltransferases Logistic Models Microbial Sensitivity Tests Muramoylpentapeptide Carboxypeptidase Neisseria Meningitidis Penicillin-Binding Proteins Penicillin G Peptidyl Transferases Perspective Streptococcus Pneumoniae
Source:

Emerg Infect Dis. 9(4):411-417
Pubmed ID:

12702219
Pubmed Central ID:

PMC2957969
Document Type:

Journal Article
Volume:

9
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:053b60fa651c71641b7fd807561077850d1898d9c1f59bcef4b13f8677ea3e2a
Download URL:

https://stacks.cdc.gov/view/cdc/13992/cdc_13992_DS1.pdf
File Type:

[PDF - 376.77 KB ]

File Language:

English

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