Legionnaires’ Disease at a Dutch Flower Show: Prognostic Factors and Impact of Therapy

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lettinga, Kamilla D. ; Verbon, Annelies ; Weverling, Gerrit-Jan ; Schellekens, Joop F.P. ; Den Boer, Jeroen W. ; Yzerman, Ed P.F. ; Prins, Jacobus ; Boersma, Wim G. ; van Ketel, Ruud J. ; Prins, Jan M. ; Speelman, Peter
  More +
• Description:
  After a large outbreak of Legionnaires' disease in the Netherlands, we determined risk factors for intensive care unit (ICU) admission and death and the impact of adequate therapy on ICU-free survival among 141 hospitalized patients. Overall mortality rate was 13%, and ICU mortality rate was 36%. Smoking, temperature >38.5 degrees C, and bilateral infiltrates shown on chest x-ray were independent risk factors for ICU admission or death (all p<0.05). Starting adequate therapy within 24 hours after admission resulted in a higher ICU-free survival rate compared to therapy initiation after 24 hours: 78% versus 54%, respectively (p=0.005). However, delay in providing therapy to patients with urinary antigen tests with negative results did not influence outcome. These data suggest that by using the urinary antigen test on admission a more tailored approach to patients with community-acquired pneumonia may be applied.
• Subjects:
  • Research
  • Community acquired infections
  • Legionella pneumophila
  • Legionnaires’ disease
  • intensive care units
  • antibiotics
  • prognosis
  • risk factors
  • Aged
  • Anti-Bacterial Agents
  More +
• Source:
  Emerg Infect Dis. 8(12):1448-1454.
• Document Type:
  Journal Article
• Volume:
  8
• Issue:
  12
• Download URL:
  https://stacks.cdc.gov/view/cdc/13923/cdc_13923_DS1.pdf
• File Type:
  [PDF - 352.50 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9b1cf551ab8eb272c5c76e52057436046f93df06da80d4c75580d64bf95fd324