Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Glynn, Judith R. ; Whiteley, Jennifer ; Bifani, Pablo J. ; Kremer, Kristin ; van Soolingen, Dick
Glynn, Judith R. ; Whiteley, Jennifer ; Bifani, Pablo J. ; Kremer, Kristin ; van Soolingen, Dick Less -
Description:
Strains of the Beijing/W genotype family of Mycobacterium tuberculosis have caused large outbreaks of tuberculosis, sometimes involving multidrug resistance. This genetically highly conserved family of M. tuberculosis strains predominates in some geographic areas. We have conducted a systematic review of the published reports on these strains to determine their worldwide distribution, spread, and association with drug resistance. Sixteen studies reported prevalence of Beijing strains defined by spoligotyping; another 10 used other definitions. Beijing strains were most prevalent in Asia but were found worldwide. Associations with drug resistance varied: in New York, Cuba, Estonia, and Vietnam, Beijing strains were strongly associated with drug resistance, but elsewhere the association was weak or absent. Although few reports have measured trends in prevalence, the ubiquity of the Beijing strains and their frequent association with outbreaks and drug resistance underline their importance.
Subject:
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Beijing Family
Drug Resistance, Multiple, Bacterial
Genotype
Humans
Molecular Epidemiology
Mycobacterium Tuberculosis
Prevalence
Resistance
Spread
Synopsis
Tuberculosis

Source:
Emerg Infect Dis. 8(8):843-849.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:a2998e09390866220a73f890f7ec2c6d109f94f34054f7e24071e73ff6b2a277
File Type:

Supporting Files

• 	02-0002-F.gif	gif
  	02-0002-F.jpg	jpeg
  	02-0002_FinalS.nxml	txt
  	license.txt	txt

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