Hep-2–Adherent Escherichia coli Strains Associated with Acute Infantile Diarrhea, São Paulo, Brazil

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Scaletsky, Isabel C. A. ; Fabbricotti, Sandra H. ; Silva, Sueli O. C. ; Morais, Mauro B. ; Fagundes-Neto, Ulysses
• Description:
  In this paired case-control study of infants with diarrhea in São Paulo, we examined the association between HEp-2-adherent Escherichia coli strains and diarrhea. We tested isolates from stool specimens of infants with diarrhea and matched controls in an HEp-2 cell adherence assay; we then hybridized isolates with DNA probes and identified enteropathogenic E. coli (EPEC), enteroaggregative E. coli (EAEC), and diffusely adherent E. coli (DAEC). From 100 patient-control pairs, we isolated 78 HEp-2-adherent strains; of these, 61 strains were single pathogens identified in stools of infants with diarrhea. While typical EPEC was significantly associated with diarrhea (p<0.001), EAEC was more frequently associated with diarrhea in clinical cases (20%) compared with healthy controls (3%) (p<0.001). Atypical EPEC, showing a localized adherence-like pattern, was also more common in patients than controls (p>0.1). DAEC was isolated with equal frequency from patients and controls (p>0.1).
• Subjects:
  Bacterial Adhesion Case-Control Studies Cell Line Diarrhea, Infantile Escherichia Coli Escherichia Coli Infections Female Humans Infant Male
• Source:
  Emerg Infect Dis. 8(8):855-858.
• Document Type:
  Journal Article
• Genre:
  Dispatch
• Place as Subject:
  Brazil
• Volume:
  8
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3a5d8756d6c079d9fdc4fd252ef3e16c0ed107858493ab72b1f379ae162ee9a1
• Download URL:
  https://stacks.cdc.gov/view/cdc/13883/cdc_13883_DS1.pdf
• File Type:
  [PDF - 186.29 KB ]