Antecedent Treatment with Different Antibiotic Agents as a Risk Factor for Vancomycin-Resistant Enterococcus

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Carmeli, Yehuda ; Eliopoulos, George M. ; Samore, Matthew H.
• Description:
  We conducted a matched case-control study to compare the effect of antecedent treatment with various antibiotics on subsequent isolation of vancomycin-resistant Enterococcus (VRE); 880 in-patients; 233 VRE cases, and 647 matched controls were included. After being matched for hospital location, calendar time, and duration of hospitalization, the following variables predicted VRE positivity: main admitting diagnosis; a coexisting condition (e.g., diabetes mellitus, organ transplant, or hepatobiliary disease); and infection or colonization with methicillin-resistant Staphylococcus aureus or Clostridium difficile within the past year (independent of vancomycin treatment). After controlling for these variables, we examined the effect of various antibiotics. Intravenous treatment with third-generation cephalosporins, metronidazole, and fluoroquinolones was positively associated with VRE. In our institution, when we adjusted the data for temporo-spatial factors, patient characteristics, and hospital events, treatment with third-generation cephalosporins, metronidazole, and fluoroquinolones was identified as a risk factor for VRE. Vancomycin was not a risk factor for isolation of VRE.
• Subjects:
  • Research
  • vancomycin
  • Enterococcus
  • resistance
  • risk factor
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents
  More +
• Source:
  Emerg Infect Dis. 8(8):802-807.
• Document Type:
  Journal Article
• Volume:
  8
• Issue:
  8
• Download URL:
  https://stacks.cdc.gov/view/cdc/13861/cdc_13861_DS1.pdf
• File Type:
  [PDF - 230.01 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8527d49e88fcb929f0d09f9758fdce958ca1bc842576d7dbf7a63448b2d4facd