Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Carmeli, Yehuda ; Eliopoulos, George M. ; Samore, Matthew H.
Carmeli, Yehuda ; Eliopoulos, George M. ; Samore, Matthew H. Less -
Description:
We conducted a matched case-control study to compare the effect of antecedent treatment with various antibiotics on subsequent isolation of vancomycin-resistant Enterococcus (VRE); 880 in-patients; 233 VRE cases, and 647 matched controls were included. After being matched for hospital location, calendar time, and duration of hospitalization, the following variables predicted VRE positivity: main admitting diagnosis; a coexisting condition (e.g., diabetes mellitus, organ transplant, or hepatobiliary disease); and infection or colonization with methicillin-resistant Staphylococcus aureus or Clostridium difficile within the past year (independent of vancomycin treatment). After controlling for these variables, we examined the effect of various antibiotics. Intravenous treatment with third-generation cephalosporins, metronidazole, and fluoroquinolones was positively associated with VRE. In our institution, when we adjusted the data for temporo-spatial factors, patient characteristics, and hospital events, treatment with third-generation cephalosporins, metronidazole, and fluoroquinolones was identified as a risk factor for VRE. Vancomycin was not a risk factor for isolation of VRE.
Subjects:
[+]
Adolescent Adult Aged Aged, 80 And Over Anti-Bacterial Agents Anti-Infective Agents Case-Control Studies Cephalosporins Enterococcus Fluoroquinolones Gram-Positive Bacterial Infections Humans Metronidazole Middle Aged Research Resistance Risk Factor Risk Factors Vancomycin Vancomycin Resistance
Source:
Emerg Infect Dis. 8(8):802-807.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:8527d49e88fcb929f0d09f9758fdce958ca1bc842576d7dbf7a63448b2d4facd
Download URL:
https://stacks.cdc.gov/view/cdc/13861/cdc_13861_DS1.pdf
File Type:

Supporting Files

• 	01-0418_FinalR.nxml	txt
  	license.txt	txt

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