Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan

Yu, Wen Leong; Pfaller, Michael A.; Winokur, Patricia L.; Jones, Ronald N.

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Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan

Published Date:

May 2002

Source:

Emerg Infect Dis. 8(5):522-524.

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Details:

Personal Authors:

Yu, Wen Leong ; Pfaller, Michael A. ; Winokur, Patricia L. ; Jones, Ronald N. ;

Keywords:

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Description:

To guide selection of carbapenems or fourth-generation cephalosporins as therapy, 110 Klebsiella pneumoniae isolates with extended-spectrum beta-lactamases from Taiwan were characterized by phenotypic (MICs), molecular, and chemical methods. MIC patterns of ceftazidime and cefepime clearly differentiate strains treatable by cefepime and those capable of efficiently hydrolyzing available cephalosporins (CTX-M series and SHV-types). Continued use of cefepime appears to be a treatment option in cases for which MIC results are available and interpreted by the criteria presented.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

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