Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Yu, Wen Leong ; Pfaller, Michael A. ; Winokur, Patricia L. ; Jones, Ronald N.
• Description:
  To guide selection of carbapenems or fourth-generation cephalosporins as therapy, 110 Klebsiella pneumoniae isolates with extended-spectrum beta-lactamases from Taiwan were characterized by phenotypic (MICs), molecular, and chemical methods. MIC patterns of ceftazidime and cefepime clearly differentiate strains treatable by cefepime and those capable of efficiently hydrolyzing available cephalosporins (CTX-M series and SHV-types). Continued use of cefepime appears to be a treatment option in cases for which MIC results are available and interpreted by the criteria presented.
• Subjects:
  Beta-Lactamases Carbapenems Cefepime Cephalosporins CTX-M Enzymes Dispatch Drug Resistance, Multiple, Bacterial Extended-spectrum β-lactamases Humans Klebsiella Pneumoniae Microbial Sensitivity Tests Phenotype Taiwan

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• Source:
  Emerg Infect Dis. 8(5):522-524.
• Document Type:
  Journal Article
• Volume:
  8
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e9206522c83d9535c4bc714754f0f584e341a4dcb51f2d4a3bbaba2081092261
• Download URL:
  https://stacks.cdc.gov/view/cdc/13837/cdc_13837_DS1.pdf
• File Type:
  [PDF - 155.12 KB ]