Immunization with Heterologous Flaviviruses Protective Against Fatal West Nile Encephalitis

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Tesh, Robert B. ; Travassos da Rosa, Amelia P.A. ; Guzman, Hilda ; Araujo, Tais P. ; Xiao, Shu-Yuan
• Description:
  Prior immunization of hamsters with three heterologous flaviviruses (Japanese encephalitis virus JEV SA14-2-8 vaccine, wild-type St. Louis encephalitis virus SLEV, and Yellow fever virus YFV 17D vaccine) reduces the severity of subsequent West Nile virus (WNV) infection. Groups of adult hamsters were immunized with each of the heterologous flaviviruses; approximately 30 days later, the animals were injected intraperitoneally with a virulent New York strain of WNV. Subsequent levels of viremia, antibody response, and deaths were compared with those in nonimmune (control) hamsters. Immunity to JEV and SLEV was protective against clinical encephalitis and death after challenge with WNV. The antibody response in the sequentially infected hamsters also illustrates the difficulty in making a serologic diagnosis of WNV infection in animals (or humans) with preexisting Flavivirus immunity.
• Subjects:
  • Research
  • West Nile virus
  • viral encephalitis
  • arboviruses
  • Flavivirus
  • experimental infection
  • immune response
  • immunization
  • Japanese encephalitis virus
  • vaccines
  More +
• Source:
  Emerg Infect Dis. 8(3):245-251.
• Document Type:
  Journal Article
• Volume:
  8
• Issue:
  3
• Download URL:
  https://stacks.cdc.gov/view/cdc/13794/cdc_13794_DS1.pdf
• File Type:
  [PDF - 215.83 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9d06370c5988e7da63c0521fd58fe3db70e82550a0355eb106a75c79561ce54b