Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Gagneux, Sébastien ; Wirth, Thierry ; Hodgson, Abraham ; Ehrhard, Ingrid ; Morelli, Giovanna ; ... More +
Gagneux, Sébastien ; Wirth, Thierry ; Hodgson, Abraham ; Ehrhard, Ingrid ; Morelli, Giovanna ; Kriz, Paula ; Genton, Blaise ; Smith, Tom ; Binka, Fred ; Pluschke, Gerd ; Achtman, Mark Less -
Description:
The genetic diversity of 134 serogroup X Neisseria meningitis isolates from Africa, Europe, and North America was analyzed by multilocus sequence typing and pulsed-field gel electrophoresis. Although most European and American isolates were highly diverse, one clonal grouping was identified in sporadic disease and carrier strains isolated over the last 2 decades in the United Kingdom, the Netherlands, Germany, and the United States. In contrast to the diversity in the European and American isolates, most carrier and disease isolates recovered during the last 30 years in countries in the African meningitis belt belonged to a second clonal grouping. During the last decade, these bacteria have caused meningitis outbreaks in Niger and Ghana. These results support the development of a comprehensive conjugate vaccine that would include serogroup X polysaccharide.
Subjects:
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Alleles Electrophoresis, Gel, Pulsed-Field Humans Meningococcal Infections Neisseria Meningitidis Phylogeny Retrospective Studies Serotyping
Source:
Emerg Infect Dis. 8(5):462-466.
Document Type:
Journal Article
Place as Subject:
Africa ; Europe ; North America
Africa ; Europe ; North America Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:b6c473119c136717fbaa925dbcfa38cce7aac09bed7061dfa7156c95b307c142
Download URL:
https://stacks.cdc.gov/view/cdc/13789/cdc_13789_DS1.pdf
File Type:

Supporting Files

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