Genetic Characterization of the M RNA Segment of Crimean Congo Hemorrhagic Fever Virus Strains, China

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Papa, Anna ; Ma, Benjiang ; Kouidou, Sophie ; Tang, Qing ; Hang, Changshou ; Antoniadis, Antonis
• Description:
  We report the genetic characterization of the M RNA segment of Crimean Congo hemorrhagic fever virus (CCHFV). Two CCHFV strains isolated in Xinjiang Province, a region endemic for CCHF in northwestern China, were studied. These strains, designated BA66019 and BA8402, were isolated in 1965 and 1984 from a CCHF patient and Hyalomma ticks, respectively. Viral RNA was extracted from suckling mouse brains infected with these two strains, amplified, and sequenced. The full-length M RNA, consisting of 5.3 kb, was determined for both strains. The coding nucleotide sequences of the two strains differed from each other by 17.5% and from the reference CCHFV strain IbAr10200 by a mean of 22%, suggesting that the genus Nairovirus comprises a group of genetically highly diverse strains.
• Subjects:
  Amino Acid Sequence Animals Base Sequence Brain Gene Amplification Gene Products, Env Genetic Variation Hemorrhagic Fever, Crimean Hemorrhagic Fever Virus, Crimean-Congo Humans Mice Molecular Weight Phylogeny Polymerase Chain Reaction Protein Precursors Research RNA, Viral Sequence Alignment

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• Source:
  Emerg Infect Dis. 8(1):50-53.
• Document Type:
  Journal Article
• Place as Subject:
  China
• Location:
  Asia
• Volume:
  8
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:434af102ca347cf7c1fac565edd9b6a6dfafbccb55b08ca5b2495c4c9c28b65e
• Download URL:
  https://stacks.cdc.gov/view/cdc/13750/cdc_13750_DS1.pdf
• File Type:
  [PDF - 83.57 KB ]