Genetic Characterization of the M RNA Segment of Crimean Congo Hemorrhagic Fever Virus Strains, China
Published Date:Jan 2002
Source:Emerg Infect Dis. 8(1):50-53.
Keywords:Amino Acid Sequence
Crimean-Congo Hemorrhagic Fever
Gene Products, Env
Hemorrhagic Fever, Crimean
Hemorrhagic Fever Virus, Crimean-Congo
M RNA Segment
Polymerase Chain Reaction
Description:We report the genetic characterization of the M RNA segment of Crimean Congo hemorrhagic fever virus (CCHFV). Two CCHFV strains isolated in Xinjiang Province, a region endemic for CCHF in northwestern China, were studied. These strains, designated BA66019 and BA8402, were isolated in 1965 and 1984 from a CCHF patient and Hyalomma ticks, respectively. Viral RNA was extracted from suckling mouse brains infected with these two strains, amplified, and sequenced. The full-length M RNA, consisting of 5.3 kb, was determined for both strains. The coding nucleotide sequences of the two strains differed from each other by 17.5% and from the reference CCHFV strain IbAr10200 by a mean of 22%, suggesting that the genus Nairovirus comprises a group of genetically highly diverse strains.
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