In Utero DDT and DDE Exposure and Obesity Status of 7-Year-Old Mexican-American Children in the CHAMACOS Cohort

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• Alternative Title:
  Environ Health Perspect
• Personal Author:
  Warner, Marcella ; Schall, Raul Aguilar ; Harley, Kim G. ; Bradman, Asa ; Barr, Dana ; Eskenazi, Brenda
• Description:
  In utero exposure to endocrine disrupting compounds including dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) has been hypothesized to increase risk of obesity later in life.|The Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study is a longitudinal birth cohort of low-income Latinas living in a California agricultural community. We examined the relation of in utero DDT and DDE exposure to child obesity at 7 years of age. We also examined the trend with age (2, 3.5, 5, and 7 years) in the exposure-obesity relation.|We included 270 children with o,p´-DDT, p,p´-DDT, and p,p´-DDE concentrations measured in maternal serum during pregnancy (nanograms per gram lipid) and complete 7-year follow-up data including weight (kilograms) and height (centimeters). Body mass index (BMI; kilograms per meter squared) was calculated and obesity was defined as ≥ 95th percentile on the sex-specific BMI-for-age Centers for Disease Control and Prevention 2000 growth charts.|At 7 years, 96 (35.6%) children were obese. A 10-fold increase in o,p´-DDT, p,p´-DDT, or p,p´-DDE, was nonsignificantly associated with increased odds (OR) of obesity [o,p´-DDT adjusted (adj-) OR = 1.17, 95% CI: 0.75, 1.82; p,p´-DDT adj-OR = 1.19, 95% CI: 0.81, 1.74; p,p´-DDE adj-OR = 1.22, 95% CI: 0.72, 2.06]. With increasing age at follow-up, we observed a significant trend toward a positive association between DDT and DDE exposure and odds of obesity.|We did not find a significant positive relation between in utero DDT and DDE exposure and obesity status of 7-year-old children. However, given the observed trend with age, continued follow-up will be informative.
• Subjects:
  Body Mass Index Child Children Cohort Studies DDT Dichlorodiphenyldichloroethylene Dichlorodiphenyl Dichloroethylene Dichlorodiphenyltrichloroethane Female Fetus Humans Longitudinal Studies Mexican Americans Obesity Pregnancy Prenatal Exposure Prenatal Exposure Delayed Effects Research

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• Source:
  Environ Health Perspect. 2013; 121(5):631-636.
• Document Type:
  Journal Article
• Funding:
  P01 ES009605/ES/NIEHS NIH HHS/United States
• Volume:
  121
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9a40014ab048873d667cda7347c994705e2d8473833df066441b7a8453b2fc76
• Download URL:
  https://stacks.cdc.gov/view/cdc/13656/cdc_13656_DS1.pdf
• File Type:
  [PDF - 443.64 KB ]