Association of prenatal urinary phthalate metabolite concentrations and childhood BMI and obesity

Details

• Alternative Title:
  Pediatr Res
• Personal Author:
  Harley, Kim G. ; Berger, Kimberly ; Rauch, Stephen ; Kogut, Katherine ; Henn, Birgit Claus ; Calafat, Antonia M. ; Huen, Karen ; Eskenazi, Brenda ; Holland, Nina
• Description:
  BACKGROUND
  
  Although experiments in animals suggest that phthalates may have obesogenic effects, studies on prenatal exposure in children show inconsistent results.
  
  METHODS
  
  We measured urinary concentrations of 11 phthalate metabolites collected twice during pregnancy from mothers participating in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort study (N = 345). Height, weight, waist circumference, and percent body fat were assessed in their children between 5 and 12 years of age. We used generalized estimating equations to examine associations at each age and tested for interaction by sex.
  
  RESULTS
  
  Metabolites of diethyl phthalate (DEP), di-n-butyl phthalate (DBP), butyl benzyl phthalate, and di(2-ethylhexyl) phthalate (DEHP) were positively associated with BMI z-score, waist circumference z-score, and percent body fat at multiple ages. At age 12, we observed increased odds of being overweight/obese with each doubling of prenatal concentrations of DEP (odds ratio = 1.3; 95% confidence intervals: 1.1, 1.4), DBP (1.2; 1.0, 1.4), and DEHP (1.3; 1.0, 1.6) metabolites. Results were similar in boys and girls except for DBP metabolites and the non-specific metabolite mono-(3-carbox-ypropyl) phthalate, which showed positive associations only in boys.
  
  CONCLUSION
  
  In utero exposure to certain phthalates is associated with increased BMI and risk for overweight/obesity in childhood.
  
  
• Subjects:
  Adolescent Adult Article Body Mass Index Child Child, Preschool Cohort Studies Female Humans Male Obesity Phthalic Acids Pregnancy Prenatal Exposure Delayed Effects Young Adult

  More +
• Source:
  Pediatr Res. 82(3):405-415.
• Pubmed ID:
  28426647
• Pubmed Central ID:
  PMC5581502
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; P01 ES009605/ES/NIEHS NIH HHS/United States ; R01 ES021369/ES/NIEHS NIH HHS/United States
• Volume:
  82
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9d38c268f9a26262c51e36a10d799b975c55e30dea0e4091418733cb9cb957cd
• Download URL:
  https://stacks.cdc.gov/view/cdc/47890/cdc_47890_DS1.pdf
• File Type:
  [PDF - 746.39 KB ]