Detecting Associations between Early-Life DDT Exposures and Childhood Growth Patterns: A Novel Statistical Approach

Heggeseth, Brianna; Harley, Kim; Warner, Marcella; Jewell, Nicholas; Eskenazi, Brenda

doi:10.1371/journal.pone.0131443

i

Detecting Associations between Early-Life DDT Exposures and Childhood Growth Patterns: A Novel Statistical Approach

Supporting Files

Jun 30 2015
By Heggeseth, Brianna ; Harley, Kim ; Warner, Marcella ; ...

File Language:

English

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Alternative Title:

PLoS One
Personal Author:

Heggeseth, Brianna ; Harley, Kim ; Warner, Marcella ; Jewell, Nicholas ; Eskenazi, Brenda
Description:

It has been hypothesized that environmental exposures at key development periods such as in utero play a role in childhood growth and obesity. To investigate whether in utero exposure to endocrine-disrupting chemicals, dichlorodiphenyltrichloroethane (DDT) and its metabolite, dichlorodiphenyldichloroethane (DDE), is associated with childhood physical growth, we took a novel statistical approach to analyze data from the CHAMACOS cohort study. To model heterogeneity in the growth patterns, we used a finite mixture model in combination with a data transformation to characterize body mass index (BMI) with four groups and estimated the association between exposure and group membership. In boys, higher maternal concentrations of DDT and DDE during pregnancy are associated with a BMI growth pattern that is stable until about age five followed by increased growth through age nine. In contrast, higher maternal DDT exposure during pregnancy is associated with a flat, relatively stable growth pattern in girls. This study suggests that in utero exposure to DDT and DDE may be associated with childhood BMI growth patterns, not just BMI level, and both the magnitude of exposure and sex may impact the relationship.
Subjects:

Body Mass Index Cohort Studies DDT Dichlorodiphenyl Dichloroethylene Endocrine Disruptors Female Humans Longitudinal Studies Male Maternal Exposure Obesity Pediatric Obesity Polychlorinated Biphenyls Pregnancy Prenatal Exposure Delayed Effects Sex Factors
Source:

PLoS One. 2015; 10(6).
Pubmed ID:

26125556
Pubmed Central ID:

PMC4488365
Document Type:

Journal Article
Funding:

P01 ES009605/ES/NIEHS NIH HHS/United States ; R01 ES017054/ES/NIEHS NIH HHS/United States ; R01 OH007400/OH/NIOSH CDC HHS/United States
Volume:

10
Issue:

6
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:70f168237c3cfea2a2958cd576bf999367d0d5be40bd6b0f60d8b41c4939c336
Download URL:

https://stacks.cdc.gov/view/cdc/33128/cdc_33128_DS1.pdf
File Type:

[PDF - 459.79 KB ]

File Language:

English

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