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Influenza vaccination rates and hospitalizations among Medicaid enrollees with and without sickle cell disease, 2009–2015
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12 2021
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Source: Pediatr Blood Cancer. 68(12):e29351
[PDF-455.42 KB]
Details:
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Alternative Title:Pediatr Blood Cancer
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Personal Author:
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Description:Background:
Personswith sickle cell disease (SCD) face increased risks for pulmonary and infection-related complications. This study examines influenza vaccination coverage and estimates influenza-related morbidity among Medicaid enrollees with and without SCD.
Procedure:
Influenza vaccination coverage and hospitalizations related to influenza and pneumonia/acute chest syndrome (ACS) during each influenza season from 2009–2010 to 2014–2015 were assessed among enrollees in the IBM MarketScan® Multi-State Medicaid Database. Enrollees with SCD were identified as enrollees with greater than or equal to three claims listing SCD within a 5-year period during 2003–2017. Vaccinations were identified in outpatient claims. Hospitalizations associated with influenza or pneumonia/ACS were identified using inpatient claims. This study includes a series of cross-sectional assessments by season.
Results:
From 2009–2010 through 2014–2015 seasons, the SCD sample ranged from 5044 to 8651 enrollees; the non-SCD sample ranged from 1,841,756 to 3,796,337 enrollees. Influenza vaccination coverage was higher among enrollees with SCD compared with enrollees without SCD for all seasons (24.5%–33.6% and 18.2%–22.0%, respectively). Age-standardized rates of influenza-related hospitalizations were 20–42 times higher among SCD enrollees compared with non-SCD enrollees, and ACS/pneumonia hospitalizations were 18–29 times higher. Among enrollees with SCD, influenza-related hospitalization rates were highest among children aged 0–9 years. Among enrollees without SCD, influenza-related hospitalization rates were highest among adults aged 40–64 years.
Conclusions:
Although vaccine coverage was higher in persons with versus without SCD, efforts to increase influenza coverage further are warranted for this high-risk group, who experienced markedly higher rates of influenza and ACS/pneumonia hospitalizations during each season.
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Source:
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Pubmed ID:34542932
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Pubmed Central ID:PMC10578616
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Funding:
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Volume:68
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Issue:12
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