Longitudinal Study of Bladder Continence in Patients with Spina Bifida in the National Spina Bifida Patient Registry

Details

• Alternative Title:
  J Urol
• Personal Author:
  Liu, Tiebin ; Ouyang, Lijing ; Thibadeau, Judy ; Wiener, John S. ; Routh, Jonathan C. ; Castillo, Heidi ; Castillo, Jonathan ; Freeman, Kurt A. ; Sawin, Kathleen J. ; Smith, Kathryn ; Van Speybroeck, Alexander ; Valdez, Rodolfo
• Description:
  Purpose
  
  Achieving bladder continence in individuals with spina bifida is a lifetime management goal. We investigated bladder continence status through time and factors associated with this status in patients with spina bifida.
  
  Materials and Methods
  
  We used National Spina Bifida Patient Registry data collected from 2009 through 2015 and applied generalized estimating equation models to analyze factors associated with bladder continence status.
  
  Results
  
  This analysis included 5,250 participants with spina bifida in a large, multi-institutional patient registry who accounted for 12,740 annual clinic visit records during the study period. At last followup mean age was 16.6 years, 22.4% of participants had undergone bladder continence surgery, 92.6% used some form of bladder management and 45.8% reported bladder continence. In a multivariable regression model the likelihood of bladder continence was significantly greater in those who were older, were female, were nonHispanic white, had a nonmyelomeningocele diagnosis, had a lower level of lesion, had a higher mobility level and had private insurance. Continence surgery history and current management were also associated with continence independent of all other factors (adjusted OR and 95% CI 1.9, 1.7–2.1 and 3.8, 3.2–4.6, respectively). The association between bladder management and continence was stronger for those with a myelomeningocele diagnosis (adjusted OR 4.6) than with non-myelomeningocele (adjusted OR 2.8).
  
  Conclusions
  
  In addition to demographic, social and clinical factors, surgical intervention and bladder management are significantly and independently associated with bladder continence status in individuals with spina bifida. The association between bladder management and continence is stronger in those with myelomeningocele.
  
  
• Keywords:
  Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Female Follow-Up Studies Humans Incidence Longitudinal Studies Male Middle Aged Prognosis Registries Retrospective Studies Spinal Dysraphism Time Factors United States Urinary Bladder, Neurogenic Urination Urologic Surgical Procedures Young Adult

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• Source:
  J Urol. 199(3):837-843
• Pubmed ID:
  29132982
• Pubmed Central ID:
  PMC5948157
• Document Type:
  Journal Article
• Funding:
  U01DD001065/ACL/ACL HHSUnited States/ ; U01DD001080/ACL/ACL HHSUnited States/ ; U01 DD001069/DD/NCBDD CDC HHSUnited States/ ; U01 DD001078/DD/NCBDD CDC HHSUnited States/ ; U01 DD001278/DD/NCBDD CDC HHSUnited States/ ; U01DD001093/ACL/ACL HHSUnited States/ ; U01DD001082/ACL/ACL HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01DD001069/ACL/ACL HHSUnited States/ ; U01DD001073/ACL/ACL HHSUnited States/ ; U01 DD001080/DD/NCBDD CDC HHSUnited States/ ; U01DD001063/ACL/ACL HHSUnited States/ ; U01DD001074/ACL/ACL HHSUnited States/ ; U01 DD001087/DD/NCBDD CDC HHSUnited States/ ; U01 DD001074/DD/NCBDD CDC HHSUnited States/ ; U01 DD001082/DD/NCBDD CDC HHSUnited States/ ; U01 DD001093/DD/NCBDD CDC HHSUnited States/ ; U01 DD001071/DD/NCBDD CDC HHSUnited States/ ; U01 DD001063/DD/NCBDD CDC HHSUnited States/ ; U01 DD001073/DD/NCBDD CDC HHSUnited States/ ; U01DD001071/ACL/ACL HHSUnited States/ ; U01DD001062/ACL/ACL HHSUnited States/ ; U01 DD001265/DD/NCBDD CDC HHSUnited States/ ; U01 DD001070/DD/NCBDD CDC HHSUnited States/ ; U01 DD001062/DD/NCBDD CDC HHSUnited States/ ; U01DD001078/ACL/ACL HHSUnited States/ ; U01 DD001065/DD/NCBDD CDC HHSUnited States/ ; U01 DD001091/DD/NCBDD CDC HHSUnited States/ ; U01DD001091/ACL/ACL HHSUnited States/
• Volume:
  199
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d32e06e6483e88e1a243448250caae1e76ad5e2abdfa89aee7547c9cab2f6f4a
• Download URL:
  https://stacks.cdc.gov/view/cdc/53987/cdc_53987_DS1.pdf
• File Type:
  [PDF - 75.43 KB ]