Outbreak of NDM-1– and OXA-181–Producing Klebsiella pneumoniae Bloodstream Infections in a Neonatal Unit, South Africa

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Magobo, Rindidzani E. ; Ismail, Husna ; Lowe, Michelle ; Strasheim, Wilhelmina ; Mogokotleng, Ruth ; Perovic, Olga ; Kwenda, Stanford ; Ismail, Arshad ; Makua, Manala ; Bore, Abram ; Phayane, Rose ; Naidoo, Harishia ; Dennis, Tanya ; Ngobese, Makhosazane ; Wijnant, Wim ; Govender, Nelesh P.
  More +
• Corporate Authors:
  for Baby GERMS-SA1
• Description:
  After an increase in carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infections and associated deaths in the neonatal unit of a South Africa hospital, we conducted an outbreak investigation during October 2019-February 2020 and cross-sectional follow-up during March 2020-May 2021. We used genomic and epidemiologic data to reconstruct transmission networks of outbreak-related clones. We documented 31 cases of culture-confirmed CRKP infection and 14 deaths. Two outbreak-related clones (bla| sequence type ST 152 n = 16 and bla| ST307 n = 6) cocirculated. The major clone bla| ST152 accounted for 9/14 (64%) deaths. Transmission network analysis identified possible index cases of bla| ST307 in October 2019 and bla| ST152 in November 2019. During the follow-up period, 11 new cases of CRKP infection were diagnosed; we did not perform genomic analysis. Sustained infection prevention and control measures, adequate staffing, adhering to bed occupancy limits, and antimicrobial stewardship are key interventions to control such outbreaks.
• Subjects:
  • Infant, Newborn
  • Humans
  • Bacterial Proteins
  • Cross-Sectional Studies
  • Klebsiella Infections
  • beta-Lactamases
  • Carbapenem-Resistant Enterobacteriaceae
  • Disease Outbreaks
  • Sepsis
  • Anti-Bacterial Agents
  More +
• Source:
  Emerg Infect Dis. 2023; 29(8):1531-1539
• Pubmed ID:
  37486166
• Pubmed Central ID:
  PMC10370860
• Document Type:
  Journal Article
• Funding:
  INV-008112/GATES/Bill & Melinda Gates FoundationUnited States/
• Place as Subject:
  South Africa
• Volume:
  29
• Issue:
  8
• Download URL:
  https://stacks.cdc.gov/view/cdc/132630/cdc_132630_DS1.pdf
• File Type:
  [PDF - 1.37 MB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:cb74048228fc3c774e6266bdef3b13326379bc1028e99f25510d7b5d4ae12780