Multidrug-Resistant Bacterial Colonization and Infections in Large Retrospective Cohort of Mechanically Ventilated COVID-19 Patients1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Mangioni, Davide ; Chatenoud, Liliane ; Colombo, Jacopo ; Palomba, Emanuele ; Guerrero, Fernando A. ; Bolis, Matteo ; Bottino, Nicola ; Breda, Giuseppe ; Chiaruttini, Maria V. ; Fior, Gabriele ; Marotta, Manuela ; Massobrio, Giovanni ; Matinato, Caterina ; Muscatello, Antonio ; Previtali, Paola ; Santambrogio, Sara ; Tardini, Francesca ; Zuglian, Gianluca ; Grasselli, Giacomo ; Fumagalli, Roberto ; Gori, Andrea ; Stocchetti, Nino ; Monti, Gianpaola ; Bandera, Alessandra
  More +
• Corporate Authors:
  MDR in FIERA Study Group
• Description:
  Few data are available on incidence of multidrug-resistant organism (MDRO) colonization and infections in mechanically ventilated patients, particularly during the COVID-19 pandemic. We retrospectively evaluated all patients admitted to the COVID-19 intensive care unit (ICU) of Hub Hospital in Milan, Italy, during October 2020‒May 2021. Microbiologic surveillance was standardized with active screening at admission and weekly during ICU stay. Of 435 patients, 88 (20.2%) had MDROs isolated ≤48 h after admission. Of the remaining patients, MDRO colonization was diagnosed in 173 (51.2%), MDRO infections in 95 (28.1%), and non-MDRO infections in 212 (62.7%). Non-MDRO infections occurred earlier than MDRO infections (6 days vs. 10 days; p<0.001). Previous exposure to antimicrobial drugs within the ICU was higher in MDRO patients than in non-MDRO patients (116/197 58.9% vs. 18/140 12.9%; p<0.001). Our findings might serve as warnings for future respiratory viral pandemics and call for increased measures of antimicrobial stewardship and infection control.
• Subjects:
  • Research
  • Multidrug-Resistant Bacterial Colonization and Infections in Large Retrospective Cohort of Mechanically Ventilated COVID-19 Patients
  • antimicrobial resistance
  • multidrug resistant
  • MDR
  • multidrug-resistant bacteria
  • bacteria
  • multidrug-resistant organism
  • MDRO
  • colonization
  More +
• Source:
  Emerg Infect Dis. 2023; 29(8):1598-1607
• Pubmed ID:
  37486196
• Pubmed Central ID:
  PMC10370845
• Document Type:
  Journal Article
• Volume:
  29
• Issue:
  8
• Download URL:
  https://stacks.cdc.gov/view/cdc/132615/cdc_132615_DS1.pdf
• File Type:
  [PDF - 1.91 MB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:0bf7ed610c033745a945f1947b07ee3306e4a945920225e657739feb79b80dc7