Long-term Cancer Outcome After Bariatric Surgery
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9 2023
Source: Obesity (Silver Spring). 31(9):2386-2397
Details:
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Alternative Title:Obesity (Silver Spring)
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Description:OBJECTIVE
Obesity is associated with increased cancer risk. Due to substantial and sustained weight loss following bariatric surgery, post-surgical patients are ideal to study the association of weight loss and cancer.
METHODS
Retrospectively (1982–2019), 21,837 bariatric surgical patients (surgery, 1982–2018) were matched 1:1 by age, sex, and BMI with non-surgical subjects. Procedures included gastric bypass, gastric banding, sleeve gastrectomy, and duodenal switch. Primary outcomes included cancer incidence and mortality, stratified by obesity- and non-obesity-related cancers, sex, cancer stage, and procedure.
RESULTS
Bariatric surgery patients had 25% lower risk of developing any cancers compared with non-surgery subjects (hazard ratio (HR) 0.75; 95% CI, 0.69–0.81; p<0.001). Cancer incidence was lower among female (HR 0.67; 95% CI, 0.62–0.74; p<0.001) but not male surgical patients, with the HR lower for females than for males (p<0.001). Female surgical patients had 41% lower risk for obesity related cancers (i.e., breast, ovarian, uterine, and colon) compared with non-surgical female subjects; HR 0.59; 95% CI, 0.52–0.66; p<0.001. Cancer mortality was significantly lower after surgery in females (HR 0.53; 95% CI, 0.44–0.64; p<0.001).
CONCLUSIONS
Bariatric surgery was associated with lower all-cancer and obesity-related cancer incidence among female patients. Cancer mortality was significantly lower among female surgical versus non-surgical subjects.
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Pubmed ID:37605634
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Pubmed Central ID:PMC10449359
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