Long-term Cancer Outcome After Bariatric Surgery

Details

• Alternative Title:
  Obesity (Silver Spring)
• Personal Author:
  Adams, Ted D. ; Meeks, Huong ; Fraser, Alison ; Davidson, Lance E. ; Holmen, John ; Newman, Michael ; Ibele, Anna R. ; Playdon, Mary ; Hardikar, Sheetal ; Richards, Nathan ; Hunt, Steven C. ; Kim, Jaewhan
• Description:
  OBJECTIVE
  
  Obesity is associated with increased cancer risk. Due to substantial and sustained weight loss following bariatric surgery, post-surgical patients are ideal to study the association of weight loss and cancer.
  
  METHODS
  
  Retrospectively (1982–2019), 21,837 bariatric surgical patients (surgery, 1982–2018) were matched 1:1 by age, sex, and BMI with non-surgical subjects. Procedures included gastric bypass, gastric banding, sleeve gastrectomy, and duodenal switch. Primary outcomes included cancer incidence and mortality, stratified by obesity- and non-obesity-related cancers, sex, cancer stage, and procedure.
  
  RESULTS
  
  Bariatric surgery patients had 25% lower risk of developing any cancers compared with non-surgery subjects (hazard ratio (HR) 0.75; 95% CI, 0.69–0.81; p<0.001). Cancer incidence was lower among female (HR 0.67; 95% CI, 0.62–0.74; p<0.001) but not male surgical patients, with the HR lower for females than for males (p<0.001). Female surgical patients had 41% lower risk for obesity related cancers (i.e., breast, ovarian, uterine, and colon) compared with non-surgical female subjects; HR 0.59; 95% CI, 0.52–0.66; p<0.001. Cancer mortality was significantly lower after surgery in females (HR 0.53; 95% CI, 0.44–0.64; p<0.001).
  
  CONCLUSIONS
  
  Bariatric surgery was associated with lower all-cancer and obesity-related cancer incidence among female patients. Cancer mortality was significantly lower among female surgical versus non-surgical subjects.
  
  
• Subjects:
  Bariatric Surgery Female Humans Male Neoplasms Obesity Retrospective Studies Weight Loss
• Keywords:
  Bariatric Surgery Body Mass Index (BMI) Cancer Severe Obesity
• Source:
  Obesity (Silver Spring). 31(9):2386-2397
• Pubmed ID:
  37605634
• Pubmed Central ID:
  PMC10449359
• Document Type:
  Journal Article
• Funding:
  R21 DK099619/DK/NIDDK NIH HHSUnited States/ ; NU58DP006320/CC/CDC HHSUnited States/ ; HHSN261201800016C/CA/NCI NIH HHSUnited States/ ; U01 CA272529/CA/NCI NIH HHSUnited States/ ; HHSN261201800016I/CA/NCI NIH HHSUnited States/ ; Z01 DK055006/ImNIH/Intramural NIH HHSUnited States/ ; R01 DK055006/DK/NIDDK NIH HHSUnited States/ ; M01 RR000064/RR/NCRR NIH HHSUnited States/
• Volume:
  31
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:ae4ae31b051ce8bb9b4e600948153b5142c03a711f3caf40c743afd4f4a8f65a4afc704bfefbab744a8d8167c3b2faa0461e54e146ede5b7b1806d741513fb77
• Download URL:
  https://stacks.cdc.gov/view/cdc/132370/cdc_132370_DS1.pdf
• File Type:
  [PDF - 1.00 MB ]