Long-Term All-Cause and Cause-Specific Mortality for Four Bariatric Surgery Procedures

Details

• Alternative Title:
  Obesity (Silver Spring)
• Personal Author:
  Adams, Ted D. ; Meeks, Huong ; Fraser, Alison ; Davidson, Lance E. ; Holmen, John ; Newman, Michael ; Ibele, Anna R. ; Richards, Nathan ; Hunt, Steven C. ; Kim, Jaewhan
• Description:
  OBJECTIVE
  
  This retrospective study incorporated long-term mortality results after different bariatric surgery procedures and for multiple age-at-surgery groups.
  
  METHODS
  
  Subjects with bariatric surgery (Surgery) and without (Non-surgery) were matched (1:1) for age, sex, BMI, and surgery date with a driver license application/renewal date. Mortality rates were compared by Cox regression, stratified by sex, surgery type, and age-at-surgery.
  
  RESULTS
  
  Subjects included 21,837 matched Surgery and Non-surgery pairs. Follow-up was up to 40 years (mean 13.2±9.5 years). All-cause mortality was 16% lower in Surgery compared to Non-surgery groups (hazard ratio, 0.84; 95% CI 0.79 to 0.90; p<0.001). Significantly lower mortality after bariatric surgery was observed for both females and males. Mortality after Surgery versus Non-surgery decreased significantly by 29%, 43%, and 72% for cardiovascular disease, cancer, and diabetes, respectively. The hazard ratio for suicide was 2.4 times higher in Surgery compared to Non-surgery subjects (95% CI 1.57–3.68; p<0.001), primarily in subjects with ages at surgery between 18–34 years.
  
  CONCLUSIONS
  
  Reduced all-cause mortality was durable for multiple decades, for multiple bariatric surgical procedures, for females and males, and irrespective of age at surgery. Rate of death from suicide was significantly higher in Surgery vs. Non-surgery subjects only in the youngest age-at-surgery subjects.
  
  
• Subjects:
  Adolescent Adult Bariatric Surgery Cardiovascular Diseases Cause Of Death Diabetes Mellitus Female Humans Male Retrospective Studies Young Adult

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• Keywords:
  Alzheimer's Disease Alzheimer's Disease Sequencing Project Antiviral Agents Bariatric Surgery BMI Herpes Simplex Human Papillomavirus Mortality Obesity Torque Teno Viruses Whole Exome Sequencing Whole Genome Sequencing

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• Source:
  Obesity (Silver Spring). 31(2):574-585
• Pubmed ID:
  36695060
• Pubmed Central ID:
  PMC9881843
• Document Type:
  Journal Article
• Funding:
  R21 DK099619/DK/NIDDK NIH HHSUnited States/ ; NU58DP006320/CC/CDC HHSUnited States/ ; UL1 TR002538/TR/NCATS NIH HHSUnited States/ ; HHSN261201800016C/CA/NCI NIH HHSUnited States/ ; U01 CA272529/CA/NCI NIH HHSUnited States/ ; HHSN261201800016I/CA/NCI NIH HHSUnited States/ ; Z01 DK055006/ImNIH/Intramural NIH HHSUnited States/ ; R01 DK055006/DK/NIDDK NIH HHSUnited States/ ; M01 RR000064/RR/NCRR NIH HHSUnited States/
• Volume:
  31
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:9455a8e6e4a298cb02646921e85e1e86f1c86d4808834e575848149f95dd6086275ad54282f4b202b5b3c336fdcf274298d8c49c3874cbca9b265ec4cb6fbedf
• Download URL:
  https://stacks.cdc.gov/view/cdc/147760/cdc_147760_DS1.pdf
• File Type:
  [PDF - 2.43 MB ]