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Long-Term All-Cause and Cause-Specific Mortality for Four Bariatric Surgery Procedures
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2 2023
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Source: Obesity (Silver Spring). 31(2):574-585
[PDF-2.43 MB]
Details:
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Alternative Title:Obesity (Silver Spring)
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Personal Author:
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Description:OBJECTIVE
This retrospective study incorporated long-term mortality results after different bariatric surgery procedures and for multiple age-at-surgery groups.
METHODS
Subjects with bariatric surgery (Surgery) and without (Non-surgery) were matched (1:1) for age, sex, BMI, and surgery date with a driver license application/renewal date. Mortality rates were compared by Cox regression, stratified by sex, surgery type, and age-at-surgery.
RESULTS
Subjects included 21,837 matched Surgery and Non-surgery pairs. Follow-up was up to 40 years (mean 13.2±9.5 years). All-cause mortality was 16% lower in Surgery compared to Non-surgery groups (hazard ratio, 0.84; 95% CI 0.79 to 0.90; p<0.001). Significantly lower mortality after bariatric surgery was observed for both females and males. Mortality after Surgery versus Non-surgery decreased significantly by 29%, 43%, and 72% for cardiovascular disease, cancer, and diabetes, respectively. The hazard ratio for suicide was 2.4 times higher in Surgery compared to Non-surgery subjects (95% CI 1.57–3.68; p<0.001), primarily in subjects with ages at surgery between 18–34 years.
CONCLUSIONS
Reduced all-cause mortality was durable for multiple decades, for multiple bariatric surgical procedures, for females and males, and irrespective of age at surgery. Rate of death from suicide was significantly higher in Surgery vs. Non-surgery subjects only in the youngest age-at-surgery subjects.
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Pubmed ID:36695060
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Pubmed Central ID:PMC9881843
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Funding:
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Volume:31
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Issue:2
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