MERS-CoV‒Specific T-Cell Responses in Camels after Single MVA-MERS-S Vaccination

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Meyer zu Natrup, Christian ; Schünemann, Lisa-Marie ; Saletti, Giulietta ; Clever, Sabrina ; Herder, Vanessa ; Joseph, Sunitha ; Rodriguez, Marina ; Wernery, Ulrich ; Sutter, Gerd ; Volz, Asisa
• Description:
  We developed an ELISPOT assay for evaluating Middle East respiratory syndrome coronavirus (MERS-CoV)‒specific T-cell responses in dromedary camels. After single modified vaccinia virus Ankara-MERS-S vaccination, seropositive camels showed increased levels of MERS-CoV‒specific T cells and antibodies, indicating suitability of camel vaccinations in disease-endemic areas as a promising approach to control infection.
• Subjects:
  Animals Antibodies, Viral Camelus Coronavirus Coronavirus Infections Dispatch Dromedary Camels Dubai ELISPOT Assay MERS-CoV MERS-CoV‒Specific T-Cell Responses In Camels After Single MVA-MERS-S Vaccination Middle East Respiratory Syndrome Coronavirus Modified Vaccinia Virus Ankara MVA MVA-MERS-S MVA Expressing Full-length MERS-CoV Spike Protein As Antigen Respiratory Infections Spike Protein T-cell Responses T-Lymphocytes Vaccination Vaccinia Virus Viruses Zoonoses

  More +
• Source:
  Emerg Infect Dis. 2023; 29(6):1236-1239
• Pubmed ID:
  37209676
• Pubmed Central ID:
  PMC10202854
• Document Type:
  Journal Article
• Volume:
  29
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6347a276c9d1a56396448abfaf2639d1a84682f3c9f4500fce844d30f07cd4d9
• Download URL:
  https://stacks.cdc.gov/view/cdc/129722/cdc_129722_DS1.pdf
• File Type:
  [PDF - 686.25 KB ]