Case Studies and Literature Review of Francisella tularensis–Related Prosthetic Joint Infection

Ponderand, Léa; Guimard, Thomas; Lazaro, Estibaliz; Dupuy, Henry; Peuchant, Olivia; Roch, Nathalie; Deroche, Philippe; Ferry, Tristan; Maurin, Max; Hennebique, Aurélie; Boisset, Sandrine; Pelloux, Isabelle; Caspar, Yvan

doi:10.3201/eid2906.221395

i

Case Studies and Literature Review of Francisella tularensis–Related Prosthetic Joint Infection

Supporting Files Public Domain

6 2023
By Ponderand, Léa ; Guimard, Thomas ; Lazaro, Estibaliz ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Ponderand, Léa ; Guimard, Thomas ; Lazaro, Estibaliz ; Dupuy, Henry ; Peuchant, Olivia ; Roch, Nathalie ; Deroche, Philippe ; Ferry, Tristan ; Maurin, Max ; Hennebique, Aurélie ; Boisset, Sandrine ; Pelloux, Isabelle ; Caspar, Yvan
Description:

Tularemia is a zoonotic infection caused by Francisella tularensis. Its most typical manifestations in humans are ulceroglandular and glandular; infections in prosthetic joints are rare. We report 3 cases of F. tularensis subspecies holarctica-related prosthetic joint infection that occurred in France during 2016-2019. We also reviewed relevant literature and found only 5 other cases of Francisella-related prosthetic joint infections worldwide, which we summarized. Among those 8 patients, clinical symptoms appeared 7 days to 19 years after the joint placement and were nonspecific to tularemia. Although positive cultures are typically obtained in only 10% of tularemia cases, strains grew in all 8 of the patients. F. tularensis was initially identified in 2 patients by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; molecular methods were used for 6 patients. Surgical treatment in conjunction with long-term antimicrobial treatment resulted in favorable outcomes; no relapses were seen after 6 months of follow-up.
Subjects:

Animals Bacteria Case Studies And Literature Review Of Francisella Tularensis–Related Prosthetic Joint Infection F. Tularensis–Related Prosthetic Joint Infection France Francisella Tularensis Humans Prosthetic Joint Infection Synopsis Tularemia Zoonoses Zoonotic Disease
Source:

Emerg Infect Dis. 2023; 29(6):1118-1126
Pubmed ID:

37209668
Pubmed Central ID:

PMC10202857
Document Type:

Journal Article
Volume:

29
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:e04045280253c24add917d18a631be3e71cd77681983977fec7c2e3a920c920f
Download URL:

https://stacks.cdc.gov/view/cdc/129696/cdc_129696_DS1.pdf
File Type:

[PDF - 1004.83 KB ]

File Language:

English

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