Trends in and Risk Factors for Recurrent Clostridioides difficile Infection, New Haven County, Connecticut, USA, 2015–2020

Okafor, Chinenye M.; Clogher, Paula; Olson, Danyel; Niccolai, Linda; Hadler, James

doi:10.3201/eid2905.221294

i

Trends in and Risk Factors for Recurrent Clostridioides difficile Infection, New Haven County, Connecticut, USA, 2015–2020

Supporting Files Public Domain

5 2023 ; 5-2023
By Okafor, Chinenye M. ; Clogher, Paula ; Olson, Danyel
http://dx.doi.org/10.3201/eid2905.221294

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Okafor, Chinenye M. ; Clogher, Paula ; Olson, Danyel ; Niccolai, Linda ; Hadler, James
Description:

Recurrent Clostridioides difficile infection (RCDI) causes an increased burden on the healthcare system. We calculated RCDI incidence and identified factors associated with RCDI cases in New Haven County, Connecticut, USA, during 2015-2020 by using data from population-based laboratory surveillance. A subset of C. difficile cases had complete chart reviews conducted for RCDI and potentially associated variables. RCDI was defined as a positive C. difficile specimen occurring 2-8 weeks after incident C. difficile infection. We compared cases with and without RCDI by using multiple regression. RCDI occurred in 12.0% of 4,301 chart-reviewed C. difficile cases, showing a U-shaped time trend with a sharp increase in 2020, mostly because of an increase in hospital-onset cases. Malignancy (odds ratio 1.51 95% CI 1.11-2.07) and antecedent nitrofurantoin use (odds ratio 2.37 95% CI 1.23-4.58) were medical risk factors for RCDI. The 2020 increase may reflect the impact of the COVID-19 pandemic.
Subjects:
Source:

Emerg Infect Dis. 2023; 29(5):877-887
Pubmed ID:

37081745
Pubmed Central ID:

PMC10124664
Document Type:

Journal Article
Volume:

29
Issue:

5
Download URL:

https://stacks.cdc.gov/view/cdc/129091/cdc_129091_DS1.pdf
File Type:

[PDF - 1003.13 KB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:d440fa8b1cec58efd189403ef420fcd45333b19c9c220301b5b20f1800c6ae44

File Language:

English

ON THIS PAGE

Details Supporting Files

Was this page helpful?

Found an issue?

Send us an email at:

publishinghd@cdc.gov

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.