Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Details

• Alternative Title:
  Am J Clin Nutr
• Personal Author:
  Young, Melissa F. ; Ou, Jiangda ; Duong, Cam ; Luo, Hanqi ; Beyh, Yara S. ; Meng, Jiawei ; Gernand, Alison D. ; Roth, Daniel E. ; Suchdev, Parminder S.
• Description:
  Background: ; It is unclear whether 25(OH)D concentrations in children and female adults may be influenced by inflammation and thus require adjustment when estimating the population prevalence of vitamin D deficiency. ; Objectives: ; We examined correlations between inflammation biomarkers, CRP or alpha-1-acid glycoprotein (AGP), and serum 25(OH)D concentrations among preschool children (PSC; 6–59 mo) and nonpregnant females of reproductive age (FRA; 15–49 y). ; Methods: ; We analyzed cross-sectional data from 6 nationally representative nutrition surveys (Afghanistan, Cambodia, Pakistan, UK, USA, and Vietnam) conducted among PSC (n = 9880) and FRA (n = 14,749) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia project. Rank correlations between CRP or AGP and 25(OH)D concentrations were examined while taking into account complex survey design effects. ; Results: ; Among both PSC and FRA, correlations between inflammation and vitamin D biomarkers were weak and inconsistent across surveys. For PSC, correlation coefficients between CRP and 25(OH)D concentrations ranged from −0.04 to 0.08, and correlations between AGP and 25(OH)D ranged from 0.01 to 0.05. Correlation coefficients between CRP and 25(OH)D for FRA ranged from −0.11 to 0.14, and correlations between AGP and 25(OH)D concentrations ranged from −0.05 to 0.01. ; Conclusions: ; Based on the weak and inconsistent correlations between CRP or AGP and 25(OH)D, there is no rationale to adjust for these inflammation biomarkers when estimating population prevalence of vitamin D deficiency in PSC or FRA.
• Subjects:
  • Article
  • inflammation
  • vitamin D
  • BRINDA
  • preschool age children
  • females of reproductive age
  • micronutrient assessment
  • Adult
  • Child, Preschool
  • Female
  More +
• Source:
  Am J Clin Nutr. 117(1):175-181
• Pubmed ID:
  36789936
• Pubmed Central ID:
  PMC10202120
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  117
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/128782/cdc_128782_DS1.pdf
• File Type:
  [PDF - 503.15 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:052421d559815f4cbfba300c78115087f3f0f722be7c5108a753916202868f18