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Association between Traumatic Brain Injury and Suicidality using a Mediation approach and MarketScan
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12 05 2022
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Source: Inj Prev.
[PDF-234.62 KB]
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Alternative Title:Inj Prev
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Description:Introduction:
Negative outcomes, including suicidal ideation/attempts, are a major public health concern, particularly among individuals who sustain a traumatic brain injury (TBI). TBI is associated with high rates of post-injury substance use, psychiatric disorders, post-traumatic stress disorder, and sleep disturbances. This study examines the mediation effects of substance use, psychiatric disorder, and sleep disorder on the associations between TBI and suicidal ideation/attempts.
Methods:
A matched case control study using data from MarketScan databases for private health insurance and Medicaid from October 2015 to December 2018 estimated the association between TBI and suicidal ideation/attempts using a mediation approach. Individuals less than 65 years of age were included.
Results:
In the Medicaid sample, psychiatric disorders mediated 22.2% of the total effect between TBI and suicidal ideation/attempt, while substance use disorders other than opioid use disorder mediated 7.46%. In the private health insurance sample, psychiatric disorders mediated 4.18% of the total effect, opioid use disorders mediated 2.17% of the total effect, and sleep disorder mediated 1.25% of the total effect.
Conclusions:
Mediators explained less than 30% of the relationship between TBI and suicidal ideation/attempt. Findings reinforce the importance of primary prevention of TBI and monitoring patients with a TBI for risk of suicide in the first 6-12 months following injury.
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Pubmed ID:36600521
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Pubmed Central ID:PMC10198876
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