Inhalant and Additional Mucosal-Related Environmental Risks for Rheumatoid Arthritis

Details

• Alternative Title:
  Rheum Dis Clin North Am
• Personal Author:
  Luedders, Brent A. ; Mikuls, Ted R. ; Thiele, Geoffrey M. ; Poole, Jill A. ; England, Bryant R.
• Description:
  Rheumatoid arthritis (RA) occurs as the result of a complex interplay of environmental factors in a genetically susceptible individual. There is considerable evidence that the lungs may serve as an initial site of tolerance loss in the generation of RA-related autoimmunity, and several environmental inhalant exposures and lung diseases have been associated with RA risk. There is additional evidence that immune and microbial dysregulation of other mucosal sites, including the oral and gastrointestinal mucosa, may contribute to the development of RA. Epidemiologic evidence linking mucosal exposures to various environmental insults as risk determinants in RA will be reviewed.
• Keywords:
  Anticitrullinated Protein Antibodies Arthritis, Rheumatoid Autoantibodies Autoimmunity Humans Immune Tolerance Lung Mucosal Inflammation Mucous Membrane Rheumatoid Arthritis
• Source:
  Rheum Dis Clin North Am. 48(4):781-798
• Pubmed ID:
  36332995
• Pubmed Central ID:
  PMC10120871
• Document Type:
  Journal Article
• Funding:
  R01 AR077607/AR/NIAMS NIH HHSUnited States/ ; U54OH010162/ACL/ACL HHSUnited States/ ; U54 OH010162/OH/NIOSH CDC HHSUnited States/ ; U54 GM115458/GM/NIGMS NIH HHSUnited States/ ; I01 BX004660/BX/BLRD VAUnited States/ ; IK2 CX002203/CX/CSRD VAUnited States/ ; R01 OH012045/OH/NIOSH CDC HHSUnited States/
• Volume:
  48
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5b174a264f0c64f16896010b360c179784b05135af80ff9e2b67317b804982df
• Download URL:
  https://stacks.cdc.gov/view/cdc/127467/cdc_127467_DS1.pdf
• File Type:
  [PDF - 466.44 KB ]