Inhalant and Additional Mucosal-Related Environmental Risks for Rheumatoid Arthritis

Details

• Personal Author:
  England BR ; Luedders BA ; Mikuls TR ; Poole JA ; Thiele GM
• Description:
  KEY POINTS: Several inhalant exposures, including cigarette smoke, silica, and other occupational exposures, have been associated with an increased odds of developing rheumatoid arthritis (RA) in epidemiologic studies. Articular and lung manifestations in RA demonstrate a bidirectional temporal relationship with airway and lung parenchymal involvement most frequently developing after arthritis, although lung disease may be the initial presenting finding. Mucosal surfaces, particularly those within the airways and lungs, may be early sites of RA-related autoimmunity. Dysbiosis of the microbiome of the gut, oral, and lung mucosa has been identified in RA patients and may have a pathogenic role in RA. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Immune System Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Sense Organs
• Keywords:
  Anticitrullinated Protein Antibodies Author Keywords: Rheumatoid Arthritis Autoantibodies Autoimmune Diseases Autoimmunity Environmental Exposure Immune System Inhalation Lung Disease Mucosal Inflammation Mucous Membranes Rheumatoid Disorders

  More +
• ISSN:
  0889-857X
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  48
• Issue:
  4
• NIOSHTIC Number:
  nn:20067132
• Citation:
  Rheum Dis Clin North Am 2022 Nov; 48(4):781-798
• Contact Point Address:
  Bryant R. England MD, PhD, 986270 Nebraska Medicine, Omaha, NE 68198-6270
• Email:
  Bryant.england@unmc.edu
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center
• Peer Reviewed:
  True
• Start Date:
  20210901
• Source Full Name:
  Rheumatic Disease Clinics of North America
• End Date:
  20250831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d9accfb426c1ca5f9e987894835424b23080a108df925ab5d8f5480dabdb83e2435649a91bf002839047e79af63ab2e7e341a553b947a74349272cc166186210
• Download URL:
  https://stacks.cdc.gov/view/cdc/231298/cdc_231298_DS1.pdf
• File Type:
  [PDF - 483.42 KB ]