Trends in Incidence of Youth-Onset Type 1 and Type 2 Diabetes, 2002–2018: Results from the US Population-Based SEARCH for Diabetes in Youth Study

Details

• Alternative Title:
  Lancet Diabetes Endocrinol
• Personal Author:
  Wagenknecht, Lynne E. ; Lawrence, Jean M. ; Isom, Scott ; Jensen, Elizabeth T. ; Dabelea, Dana ; Liese, Angela D. ; Dolan, Lawrence M. ; Shah, Amy S. ; Bellatorre, Anna ; Sauder, Katherine ; Marcovina, Santica ; Reynolds, Kristi ; Pihoker, Catherine ; Imperatore, Giuseppina ; Divers, Jasmin
• Corporate Authors:
  SEARCH for Diabetes in Youth Study
• Description:
  Background.
  
  The incidence of diabetes is increasing in youth. Our aim was to describe the incidence of type 1 diabetes (T1D) and type 2 diabetes (T2D) in US youth aged < 20 years over a 17-year period.
  
  Methods.
  
  The SEARCH for Diabetes in Youth Study identified youth with a physician diagnosis of T1D or T2D at five US centers between 2002–2018. The number of youth at risk was obtained from the census or health plan member counts. Generalized autoregressive moving average models were used to examine trends, and data were presented as incidence per 100,000 youth across categories of age, sex, race, ethnicity, geographic region, and month/season of diagnosis.
  
  Findings.
  
  We identified 18,169 youth aged 0–19 years with T1D and 5,293 youth aged 10–19 years with T2D in over 85 million person-years. The annual incidence for T1D and T2D was 22·2/100,000 and 17·9/100,000 in 2017/2018, respectively. The model for trend captured both a linear effect and a moving average effect, with a significant increasing (annual) linear effect for both T1D (2·0%) and T2D (5·3%). Youth from racial and ethnic minority groups had greater increases in incidence for both types of diabetes. Peak age at diagnosis was 10 and 16 years, for T1D and T2D, respectively. Season was significant (p<0·001) with a January peak in T1D and an August peak in T2D.
  
  Interpretation.
  
  The increasing incidence of T1D and T2D in US youth will result in an expanding population of young adults at risk for developing early complications of diabetes, whose health care needs will exceed those of their peers. Findings regarding age and season of diagnosis will inform focused prevention efforts.
  
  Funding.
  
  Centers for Disease Control and Prevention and National Institutes of Health
  
  
• Subjects:
  Adolescent Child Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Ethnicity Humans Incidence Infant Minority Groups United States Young Adult

  More +
• Source:
  Lancet Diabetes Endocrinol. 11(4):242-250
• Pubmed ID:
  36868256
• Pubmed Central ID:
  PMC10091237
• Document Type:
  Journal Article
• Funding:
  U18DP006139/ACL/ACL HHSUnited States/ ; U18 DP006131/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006134/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006138/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006138/ACL/ACL HHSUnited States/ ; U18DP006134/ACL/ACL HHSUnited States/ ; U18DP006131/ACL/ACL HHSUnited States/ ; U18 DP006139/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006136/ACL/ACL HHSUnited States/ ; U18DP006133/ACL/ACL HHSUnited States/ ; U18 DP006136/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006133/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  11
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b4afa342d8197809bf262083bd02555a300f382027f453329cfe7134145c1a52
• Download URL:
  https://stacks.cdc.gov/view/cdc/126895/cdc_126895_DS1.pdf
• File Type:
  [PDF - 593.10 KB ]