Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Paz-Bailey, Gabriela ; Sánchez-González, Liliana ; Torres-Velasquez, Brenda ; Jones, Emma S. ; Perez-Padilla, Janice ; Sharp, Tyler M. ; Lorenzi, Olga ; Delorey, Mark ; Munoz-Jordan, Jorge L. ; Tomashek, Kay M. ; Waterman, Stephen H. ; Alvarado, Luisa I. ; Rivera-Amill, Vanessa
  More +
• Description:
  Background. ; We evaluated clinical and laboratory findings among patients with nonsevere or severe dengue in Puerto Rico to examine whether clinical manifestations vary by age. ; Methods. ; During 2012–2014, we enrolled patients who arrived at the emergency department with fever or history of fever within 7 days of presentation. Serum samples were tested for dengue virus (DENV) by reverse transcriptase-polymerase chain reaction (RT-PCR) and IgM enzyme-linked immunosorbent assay (ELISA). Severe dengue was defined as severe plasma leakage or shock, severe bleeding, or organ involvement at presentation, during hospitalization, or follow-up. ; Results. ; Of 1089 dengue patients identified, 281 (26%) were severe. Compared to those with nonsevere dengue, patients with severe dengue were more often aged 10–19 years (55% vs 40%, P < .001) and hospitalized (87% vs 30%, P < .001). Severe plasma leakage or shock was more common among children aged 0–9 (59%) or 10–19 years (86%) than adults (49%) (P < .01). Severe bleeding was less common among 10–19 year olds (24%) compared to 0–9 year olds (45%) and adults (52%; P < .01). ; Conclusions. ; Severe plasma leakage was the most common presentation among children, highlighting important differences from adults. Vaccination against dengue could help prevent severe dengue among children in Puerto Rico.
• Subjects:
  • Adult
  • Child
  • Humans
  • Dengue Virus
  • Dengue
  • Severe Dengue
• Source:
  J Infect Dis. 226(11):1949-1958
• Document Type:
  Journal Article
• Place as Subject:
  Puerto Rico
• Volume:
  226
• Issue:
  11
• Download URL:
  https://stacks.cdc.gov/view/cdc/125738/cdc_125738_DS1.pdf
• File Type:
  [PDF - 436.97 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:f2ac4476999ac6e63c44db1b283145c2602baa7e0ad88af777defa6a01da04d37cd6817c70d5573dc3e2cba2bb0da4ef3dee3fa55b9a1cd8eb9346b73bae52df