Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, China

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Zhang, Wenchao ; Yin, Mei ; Li, Wei ; Xu, Nana ; Lu, Haining ; Qin, Weidong ; Han, Hui ; Li, Chen ; Wu, Dawei ; Wang, Hao
• Description:
  Acinetobacter baumannii is a nosocomial pathogen associated with severe illness and death. Glucocorticoid aerosol is a common inhalation therapy in patients receiving invasive mechanical ventilation. We conducted a prospective cohort study to analyze the association between glucocorticoid aerosol therapy and A. baumannii isolation from ventilator patients in China. Of 497 enrolled patients, 262 (52.7%) received glucocorticoid aerosol, and A. baumannii was isolated from 159 (32.0%). Glucocorticoid aerosol therapy was an independent risk factor for A. baumannii isolation (hazard ratio 1.5, 95% CI 1.02-2.28; p = 0.038). Patients receiving glucocorticoid aerosol had a higher cumulative hazard for A. baumannii isolation and analysis showed that glucocorticoid aerosol therapy increased A. baumannii isolation in most subpopulations. Glucocorticoid aerosol was not a direct risk factor for 30-day mortality, but A. baumannii isolation was independently associated with 30-day mortality in ventilator patients. Physicians should consider potential A. baumannii infection when prescribing glucocorticoid aerosol therapy.
• Subjects:
  Acinetobacter Baumannii Acinetobacter Infections Glucocorticoids Humans Intensive Care Units Prospective Studies Respiration, Artificial Retrospective Studies
• Source:
  Emerg Infect Dis. 2022; 28(12):2398-2408
• Pubmed ID:
  36417919
• Pubmed Central ID:
  PMC9707605
• Document Type:
  Journal Article
• Place as Subject:
  China
• Volume:
  28
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:22e6ff72ba6eec4692f8b4aecb247f4d6350c1ffbface40bc7575c83ea7ed102
• Download URL:
  https://stacks.cdc.gov/view/cdc/123299/cdc_123299_DS1.pdf
• File Type:
  [PDF - 1.23 MB ]