SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice

Baz, Mariana; Deshpande, Nikita; Mackenzie-Kludas, Charlie; Mordant, Francesca; Anderson, Danielle; Subbarao, Kanta

doi:10.3201/eid2811.220718

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SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice

11 2022
By Baz, Mariana ; Deshpande, Nikita ; Mackenzie-Kludas, Charlie ; ...
http://dx.doi.org/10.3201/eid2811.220718
Source: Emerg Infect Dis. 2022; 28(11):2352-2355

[PDF-762.74 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Baz, Mariana ; Deshpande, Nikita ; Mackenzie-Kludas, Charlie ; Mordant, Francesca ; Anderson, Danielle ; ... More +

Baz, Mariana ; Deshpande, Nikita ; Mackenzie-Kludas, Charlie ; Mordant, Francesca ; Anderson, Danielle ; Subbarao, Kanta Less -
Description:

We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, although ancestral- and Delta-infected mice were protected from BA.1 infection.
Subjects:

[+]

Animals Antibodies, Neutralizing Antibodies, Viral COVID-19 Cross Reactions Mice SARS-COV-2 Spike Glycoprotein, Coronavirus Viral Envelope Proteins
Source:

Emerg Infect Dis. 2022; 28(11):2352-2355
Pubmed ID:

36191630
Pubmed Central ID:

PMC9622237
Document Type:

Journal Article
Genre:

Letter
Place as Subject:

Australia
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

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urn:sha256:57d62c730d72246a51e81e1459f38effa83aa2f361e8e269f8bb7c94fe1db78a
Download URL:

https://stacks.cdc.gov/view/cdc/122867/cdc_122867_DS1.pdf
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