Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Smits, Wiep Klaas ; Harmanus, Céline ; Sanders, Ingrid M.J.G. ; Bry, Lynn ; Blackwell, Grace A. ; Ducarmon, Quinten R. ; de Oliveira Ferreira, Eliane ; Kuijper, Ed J
• Description:
  The plasmid pCD-METRO confers metronidazole resistance in Clostridioides difficile. We showed high sequence similarity among pCD-METRO plasmids from different isolates and identified pCD-METRO and associated metronidazole-resistant isolates in clinical and veterinary reservoirs in the Americas. We recommend using PCR or genomic assays to detect pCD-METRO in metronidazole-resistant C. difficile.
• Subjects:
  Anti-Bacterial Agents Clostridioides Clostridium Infections Drug Resistance, Bacterial Metronidazole Microbial Sensitivity Tests Ribotyping
• Source:
  Emerg Infect Dis. 2022; 28(11):2308-2311
• Pubmed ID:
  36286226
• Pubmed Central ID:
  PMC9622256
• Document Type:
  Journal Article
• Funding:
  P30 DK034854/DK/NIDDK NIH HHSUnited States/ ; R01 AI153605/AI/NIAID NIH HHSUnited States/
• Genre:
  Dispatch
• Place as Subject:
  Brazil ; Netherlands ; United States
• Volume:
  28
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:1f8a937616980de7e53fcea9aa64c94712f52f9dcbe1bace6e2e8f2ee31e027d
• Download URL:
  https://stacks.cdc.gov/view/cdc/122865/cdc_122865_DS1.pdf
• File Type:
  [PDF - 922.03 KB ]