Multispecies Outbreak of Nocardia Infections in Heart Transplant Recipients and Association with Climate Conditions, Australia

Li, Jonathan; Lau, Cindy; Anderson, Naomi; Burrows, Fay; Mirdad, Feras; Carlos, Lilibeth; Pitman, Andrew J.; Muthiah, Kavitha; Darley, David R.; Andresen, David; Macdonald, Peter; Marriott, Deborah; Dharan, Nila J.

doi:10.3201/eid2811.220262

i

Multispecies Outbreak of Nocardia Infections in Heart Transplant Recipients and Association with Climate Conditions, Australia

Supporting Files Public Domain

11 2022
By Li, Jonathan ; Lau, Cindy ; Anderson, Naomi ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Li, Jonathan ; Lau, Cindy ; Anderson, Naomi ; Burrows, Fay ; Mirdad, Feras ; Carlos, Lilibeth ; Pitman, Andrew J. ; Muthiah, Kavitha ; Darley, David R. ; Andresen, David ; Macdonald, Peter ; Marriott, Deborah ; Dharan, Nila J.
Description:

A multispecies outbreak of Nocardia occurred among heart transplant recipients (HTR), but not lung transplant recipients (LTR), in Sydney, New South Wales, Australia, during 2018-2019. We performed a retrospective review of 23 HTR and LTR who had Nocardia spp. infections during June 2015-March 2021, compared risk factors for Nocardia infection, and evaluated climate conditions before, during, and after the period of the 2018-2019 outbreak. Compared with LTR, HTR had a shorter median time from transplant to Nocardia diagnosis, higher prevalence of diabetes, greater use of induction immunosuppression with basiliximab, and increased rates of cellular rejection before Nocardia diagnosis. During the outbreak, Sydney experienced the lowest monthly precipitation and driest surface levels compared with time periods directly before and after the outbreak. Increased immunosuppression of HTR compared with LTR, coupled with extreme weather conditions during 2018-2019, may explain this outbreak of Nocardia infections in HTR.
Subjects:

Basiliximab Disease Outbreaks Heart Transplantation Humans Nocardia Infections Transplant Recipients Trimethoprim, Sulfamethoxazole Drug Combination
Source:

Emerg Infect Dis. 2022; 28(11):2155-2164
Pubmed ID:

36287030
Pubmed Central ID:

PMC9622252
Document Type:

Journal Article
Place as Subject:

Australia
Volume:

28
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:fa46ce1eb50889a6c58f55fd49424b0beea719df713e63e5992dc92682396aac
Download URL:

https://stacks.cdc.gov/view/cdc/122854/cdc_122854_DS1.pdf
File Type:

[PDF - 2.28 MB ]

File Language:

English

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